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Invitrogen
PTP1B Polyclonal Antibody
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Product Details
PA5-148488
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
E. coli-derived recombinant human PTP1B, Glu2-Asn321
Conjugate
Form
Lyophilized
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with trehalose
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
PTP1B (PTPN1) is a tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. It mediates dephosphorylation of EIF2AK3/PERK and in turn inactivates the protein kinase activity of EIF2AK3/PERK. PTP1B also plays a role in CKII- and p60c-src-induced signal transduction cascades. It regulates the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. PTP1B also regulates the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CPTP1; EC 3.1.3.48; hgnc9642; KIAA0283; protein tyrosine phosphatase, placental; protein-protein-tyrosine phosphatase HA2; Protein-tyrosine phosphatase 1B; Protein-tyrosine phosphatase HA2; PTN1; PTP-1B; PTP-HA2; RP5-1121H13.2; RPTPrho; tyrosine phosphatase 1b; tyrosine-phosphatase; Tyrosine-protein phosphatase non-receptor type 1
Gene Aliases: Ptp; PTP-1B; PTP-HA2; PTP1B; PTPN1
UniProt ID: (Human) P18031, (Rat) P20417, (Mouse) P35821
Entrez Gene ID: (Human) 5770, (Rat) 24697, (Mouse) 19246
protein tyrosine phosphatase activity
insulin receptor binding
protein binding
zinc ion binding
enzyme binding
protein kinase binding
receptor tyrosine kinase binding
poly(A) RNA binding
ephrin receptor binding
protein phosphatase 2A binding
cadherin binding involved in cell-cell adhesion
phosphoprotein phosphatase activity
hydrolase activity
phosphatase activity
protein phosphatase
protein dephosphorylation
activation of signaling protein activity involved in unfolded protein response
activation of JUN kinase activity
insulin receptor signaling pathway
regulation of signal transduction
negative regulation of signal transduction
regulation of endocytosis
negative regulation of vascular endothelial growth factor receptor signaling pathway
endoplasmic reticulum unfolded protein response
actin cytoskeleton reorganization
regulation of intracellular protein transport
peptidyl-tyrosine dephosphorylation
platelet-derived growth factor receptor-beta signaling pathway
IRE1-mediated unfolded protein response
negative regulation of MAP kinase activity
negative regulation of insulin receptor signaling pathway
regulation of type I interferon-mediated signaling pathway
JAK-STAT cascade involved in growth hormone signaling pathway
positive regulation of protein tyrosine kinase activity
negative regulation of ERK1 and ERK2 cascade
cell-cell adhesion
regulation of hepatocyte growth factor receptor signaling pathway
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
positive regulation of IRE1-mediated unfolded protein response
negative regulation of PERK-mediated unfolded protein response
peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity
positive regulation of receptor catabolic process
regulation of insulin receptor signaling pathway
dephosphorylation
response to endoplasmic reticulum stress
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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