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Invitrogen

PTP1B Polyclonal Antibody

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PTP1B Polyclonal Antibody

Product Details

PA5-15521

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein encoding aa 1-321 of human PTP1B
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

2 mg/mL

Amount

800 µg

Purification

Size-exclusion - Dialysis, Ammonium sulfate precipitation

Storage buffer

PBS, pH 7.4

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2237979

Target Information

PTP1B (PTPN1) is a tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. It mediates dephosphorylation of EIF2AK3/PERK and in turn inactivates the protein kinase activity of EIF2AK3/PERK. PTP1B also plays a role in CKII- and p60c-src-induced signal transduction cascades. It regulates the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. PTP1B also regulates the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CPTP1; EC 3.1.3.48; hgnc9642; KIAA0283; phosphotyrosyl-protein phosphatase (EC 3.1.3.48); protein tyrosine phosphatase, placental; Protein-tyrosine phosphatase 1B; PTN1; PTP-1B; RP5-1121H13.2; RPTPrho; tyrosine phosphatase 1b; tyrosine-phosphatase; Tyrosine-protein phosphatase non-receptor type 1; unnamed protein product

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Gene Aliases: PTP1B; PTPN1

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UniProt ID: (Human) P18031

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Entrez Gene ID: (Human) 5770

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Function(s)
RNA binding phosphoprotein phosphatase activity protein tyrosine phosphatase activity non-membrane spanning protein tyrosine phosphatase activity insulin receptor binding protein binding zinc ion binding hydrolase activity phosphatase activity enzyme binding protein kinase binding receptor tyrosine kinase binding cadherin binding ephrin receptor binding protein phosphatase 2A binding
Process(es)
positive regulation of systemic arterial blood pressure protein dephosphorylation negative regulation of cell proliferation insulin receptor signaling pathway regulation of signal transduction negative regulation of signal transduction positive regulation of heart rate positive regulation of cardiac muscle cell apoptotic process negative regulation of cell-substrate adhesion negative regulation of neuron projection development actin cytoskeleton organization regulation of endocytosis regulation of proteolysis negative regulation of vascular endothelial growth factor receptor signaling pathway endoplasmic reticulum unfolded protein response response to nutrient levels cellular response to insulin stimulus regulation of intracellular protein transport cellular response to unfolded protein response to endoplasmic reticulum stress peptidyl-tyrosine dephosphorylation platelet-derived growth factor receptor-beta signaling pathway cellular response to platelet-derived growth factor stimulus IRE1-mediated unfolded protein response insulin receptor recycling negative regulation of MAP kinase activity cellular response to fibroblast growth factor stimulus positive regulation of JNK cascade regulation of insulin receptor signaling pathway negative regulation of insulin receptor signaling pathway negative regulation of protein kinase B signaling regulation of type I interferon-mediated signaling pathway JAK-STAT cascade involved in growth hormone signaling pathway negative regulation of ERK1 and ERK2 cascade cellular response to hypoxia cellular response to nitric oxide vascular endothelial cell response to oscillatory fluid shear stress regulation of postsynapse assembly regulation of hepatocyte growth factor receptor signaling pathway negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway positive regulation of IRE1-mediated unfolded protein response negative regulation of PERK-mediated unfolded protein response cellular response to angiotensin negative regulation of vascular associated smooth muscle cell migration cellular response to nerve growth factor stimulus response to angiotensin positive regulation of endothelial cell apoptotic process positive regulation of receptor catabolic process
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