Immunogen sequence: MTSRRWFHP NITGVEAENL LLTRGVDGSF LARPSKSNPG DFTLSVRRNG AVTHIKIQNT GDYYDLYGGE KFATLAELVQ YYMEHHGQLK EKNGDVIELK YPLNCADPTS ERWFHGHLSG KEAEKLLTEK GKHGSFLVRE SQSHPGDFVL SVRTGDDKGE SNDGKSKVTH VMIRCQELKY DVGGGERFDS LTDLVEHYKK NPMVETLGTV LQLKQPLNTT RINAAEIESR VRELSKLAET TDKVKQGFWE EFETLQQQEC KLLYSRKEGQ RQENKNKNRY KNILPFDHTR VVLHDGDPNE PVSDYINANI IMPEFETKCN NSKPKKSYIA TQGCLQNTVN DFWRMVFQEN SRVIVMTTKE VERGKSKCVK YWPDEYALKE YGVMRVRNVK ESAAHDYTLR ELKLSKVGQG NTERTVWQYH FRTWPDHGVP SDPGGVLDFL EEVHHKQESI MDAGPVVVHC R (1-460 aa encoded by BC008692)
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia.
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Protein Aliases: HCP; HGNC:9644; MGC14433; Noonan syndrome 1; OTTHUMP00000166108; Protein-tyrosine phosphatase 1D; Protein-tyrosine phosphatase 2C; PTP-1D; PTP-2C; PTP1C; SH-PTP2; SH-PTP3; SHP-2; Tyrosine-protein phosphatase non-receptor type 11
Gene Aliases: BPTP3; CFC; JMML; METCDS; NS1; PTP-1D; PTP2C; PTPN11; SH-PTP2; SH-PTP3; SHP2; SHPTP2
UniProt ID: (Human) Q06124
Entrez Gene ID: (Human) 5781
Molecular Function: protein phosphatase