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Proteintech
PTPN13 Polyclonal Antibody
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Product Details
25944-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PTPN13 Fusion Protein Ag22854 (1-350 aa encoded by BC140777)
Conjugate
Form
Liquid
Concentration
0.33 mg/mL
Amount
49.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MHVSLAEAL EVRGGPLQEE EIWAVLNQSA ESLQELFRKV SLADPAALGF IISPWSLLLL PSGSVSFTDE NISNQDLRAF TAPEVLQNQS LTSLSDVEKI HIYSLGMTLY WGADYEVPQS QPIKLGDHLN SILLGMCEDV IYARVSVRTV LDACSAHIRN SNCAPSFSYV KHLVKLVLGN LSGTDQLSCN SEQKPDRSQA IRDRLRGKGL PTGRSSTSDV LDIQKPPLSH QTFLNKGLSK SMGFLSIKDT QDENYFKDIL SDNSGREDSE NTFSPYQFKT SGPEKKPIPG IDVLSKKKIW ASSMDLLCTA DRDFSSGETA TYRRCHPEAV TVRTSTTPRK KEARYSDGSI A (1-350 aa encoded by BC140777)
Target Information
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large intracellular protein. It has a catalytic PTP domain at its C-terminus and two major structural domains: a region with five PDZ domains and a FERM domain that binds to plasma membrane and cytoskeletal elements. This PTP was found to interact with, and dephosphorylate, Fas receptor and IkappaBalpha through the PDZ domains. This suggests it has a role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathways. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: DKFZp686J1497; FAP-1; Fas-associated protein-tyrosine phosphatase 1; hPTPE1; protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase); Protein-tyrosine phosphatase 1E; Protein-tyrosine phosphatase PTPL1; PTP-BAS; PTP-E1; Tyrosine-protein phosphatase non-receptor type 13
Gene Aliases: FAP-1; hPTP1E; PNP1; PTP-BAS; PTP-BL; PTP1E; PTPL1; PTPLE; PTPN13
UniProt ID: (Human) Q12923
Entrez Gene ID: (Human) 5783
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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