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| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:500-1:2,000 | View 3 publications 3 publications |
Immunohistochemistry (IHC) |
- | View 2 publications 2 publications |
Immunohistochemistry (Paraffin) (IHC (P)) |
1:20-1:200 | - |
Immunocytochemistry (ICC/IF) |
- | View 1 publication 1 publication |
Immunoprecipitation (IP) |
0.5-4.0 µg | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Mouse |
Published species |
Human, Mouse |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
PTPN2 Fusion Protein Ag1709 (1-346 aa encoded by BC016727) |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.31 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.1% sodium azide |
Storage conditions |
-20°C |
Immunogen sequence: MPTTIEREF EELDTQRRWQ PLYLEIRNES HDYPHRVAKF PENRNRNRYR DVSPYDHSRV KLQNAENDYI NASLVDIEEA QRSYILTQGP LPNTCCHFWL MVWQQKTKAV VMLNRIVEKE SVKCAQYWPT DDQEMLFKET GFSVKLLSED VKSYYTVHLL QLENINSGET RTISHFHYTT WPDFGVPESP ASFLNFLFKV RESGSLNPDH GPAVIHCSAG IGRSGTFSLV DTCLVLMEKG DDINIKQVLL NMRKYRMGLI QTPDQLRFSY MAIIEGAKCI KGDSSIQKRW KELSKEDLSP AFDHSPNKIM TEKYNGNRIG LEEEKLTGDR CTGLSSKMQD TMEENSE (1-346 aa encoded by BC016727)
T-cell protein tyrosine phosphatase (TC-PTP), also known as PTPT and PTPN2, is an enzyme that removes phosphate groups covalently attached to tyrosine residues in proteins. This enzyme has two C-terminal end splice variants with distinctly different subcellular localizations. The shorter 45 kilodalton isoform is exclusively nuclear in resting cells, but redistrubutes to the cytosol upon stimulation with growth factors and cellular stress. The longer 48 kilodalton isoform is exclusively found in the endoplasmic reticulum 3 and seems to have distinctly different physiologic substrates from the smaller isoform. Although found in many cell types and tissues, TC-PTP is particularly prominent in hemopoietic cell types. Knockout mice lacking TC-PTP are born viable but die 3 to 5 weeks after birth of erythropoietic and lymphopoietic deficits 7, indicating a critical role for TC-PTP in bone marrow maturation. TC-PTP will dephosphorylate a wide range of phosphoproteins, such as p52 Shc 6 and receptors for EGF 1, Insulin 8 and growth hormone.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: MPTP; Protein-tyrosine phosphatase PTP-2; PTPN 2; T cell protein-tyrosine phosphatase; T-cell protein tyrosine phosphatase; T-cell protein-tyrosine phosphatase; TC PTP; TCPTP; tyrosine-phosphatase; Tyrosine-protein phosphatase non-receptor type 2
Gene Aliases: AI325124; PTN2; PTPN2; PTPT; TC-PTP; TCELLPTP; TCPTP
UniProt ID: (Human) P17706, (Mouse) Q06180
Entrez Gene ID: (Human) 5771, (Mouse) 19255
Molecular Function:
protein phosphatase
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