Invitrogen

PTPN2 Polyclonal Antibody

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PTPN2 Polyclonal Antibody

Product Details

PA5-79895

Applications
Tested Dilution
Publications

Western Blot (WB)

0.1-0.5 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

0.5-1 µg/mL
-

Immunocytochemistry (ICC/IF)

5 µg/mL
-
Product Specifications

Species Reactivity

Human, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

E.coli-derived human TCPTP recombinant protein (Position: M1-C330).
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

500 µg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS with 5mg BSA

Contains

0.05mg sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2747010

Product Specific Information

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

Positive Control - WB: HELA whole cell, JURKAT whole cell. IHC: rat kidney tissue, human intestinal cancer tissue.

Target Information

T-cell protein tyrosine phosphatase (TC-PTP), also known as PTPT and PTPN2, is an enzyme that removes phosphate groups covalently attached to tyrosine residues in proteins. This enzyme has two C-terminal end splice variants with distinctly different subcellular localizations. The shorter 45 kilodalton isoform is exclusively nuclear in resting cells, but redistrubutes to the cytosol upon stimulation with growth factors and cellular stress. The longer 48 kilodalton isoform is exclusively found in the endoplasmic reticulum 3 and seems to have distinctly different physiologic substrates from the smaller isoform. Although found in many cell types and tissues, TC-PTP is particularly prominent in hemopoietic cell types. Knockout mice lacking TC-PTP are born viable but die 3 to 5 weeks after birth of erythropoietic and lymphopoietic deficits 7, indicating a critical role for TC-PTP in bone marrow maturation. TC-PTP will dephosphorylate a wide range of phosphoproteins, such as p52 Shc 6 and receptors for EGF 1, Insulin 8 and growth hormone.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Protein-tyrosine phosphatase PTP-S; PTPN 2; T-cell protein tyrosine phosphatase; T-cell protein-tyrosine phosphatase; TC PTP; TCPTP; tyrosine-phosphatase; Tyrosine-protein phosphatase non-receptor type 2

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Gene Aliases: PTN2; PTPN2; PTPT; TC-PTP; TCELLPTP; TCPTP

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UniProt ID: (Human) P17706, (Rat) P35233

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Entrez Gene ID: (Human) 5771, (Rat) 117063

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Function(s)
protein tyrosine phosphatase activity non-membrane spanning protein tyrosine phosphatase activity integrin binding protein binding protein kinase binding syntaxin binding receptor tyrosine kinase binding DNA binding protein phosphatase
Process(es)
negative regulation of cell proliferation insulin receptor signaling pathway negative regulation of tumor necrosis factor-mediated signaling pathway negative regulation of lipid storage B cell differentiation T cell differentiation erythrocyte differentiation peptidyl-tyrosine dephosphorylation negative regulation of epidermal growth factor receptor signaling pathway negative regulation of tyrosine phosphorylation of Stat1 protein negative regulation of tyrosine phosphorylation of Stat5 protein negative regulation of tyrosine phosphorylation of Stat6 protein glucose homeostasis negative regulation of macrophage differentiation positive regulation of gluconeogenesis negative regulation of insulin receptor signaling pathway negative regulation of inflammatory response negative regulation of T cell receptor signaling pathway negative regulation of chemotaxis regulation of interferon-gamma-mediated signaling pathway negative regulation of interferon-gamma-mediated signaling pathway negative regulation of type I interferon-mediated signaling pathway negative regulation of protein tyrosine kinase activity negative regulation of interleukin-6-mediated signaling pathway negative regulation of ERK1 and ERK2 cascade regulation of hepatocyte growth factor receptor signaling pathway negative regulation of interleukin-2-mediated signaling pathway negative regulation of prolactin signaling pathway negative regulation of interleukin-4-mediated signaling pathway negative regulation of macrophage colony-stimulating factor signaling pathway negative regulation of positive thymic T cell selection positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway positive regulation of PERK-mediated unfolded protein response negative regulation of platelet-derived growth factor receptor-beta signaling pathway protein dephosphorylation negative regulation of tyrosine phosphorylation of Stat3 protein
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