Search

  • Contáctenos
  • Orden Rápida

Invitrogen

PTPN22 Polyclonal Antibody

View all (14) PTPN22 antibodies

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Datasheet
Certificates
Protocols
Questions & Answers
Tech Support
Additional Information:
{{banner.description}}
{{$ctrl.isSkuNotesCollapsed ? 'View more' : 'View less'}}
PTPN22 Polyclonal Antibody

Product Details

PA5-37401

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant full length human PTPN22
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2554046

Product Specific Information

This antibody detects endogenous protein at a molecular weight of 92 kDa.

Purity is >95% by SDS-PAGE.

Target Information

The protein tyrosine phosphatase PTPN22 (PTP22, LYP, PEP, formerly PTPN8) is a genetic variant that confers risk of developing diverse human autoimmune diseases such as type 1 diabetes and rheumatoid arthritis. The minor allele of a missense SNP in PTPN22 encodes a hematopoietic-specific protein tyrosine phosphatase also known as "Lyp." The risk allele is present in about 17% of Caucasian individuals from the general population and in approximately 28% of Caucasian individuals with rheumatoid arthritis; it is thought to disrupt the P1 proline-rich motif that is important for interaction with the Src homology-3 (SH3) domain of CSK (cytoplasmic tyrosine kinase), potentially altering the normal functions of these proteins as negative regulators of T cell activation. The interaction between CSK and PTPN22 is highly specific and it is speculated that PTPN22 may be an effector and/or regulator of CSK in T cells and other hematopoietic cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP; Lymphoid phosphatase; lymphoid-specific protein tyrosine phosphatase; LyP; LYP3; PEP; PEST domain-enriched tyrosine phosphatase; PEST-domain phosphatase; protein tyrosine phosphatase, non-receptor type 22 (lymphoid); protein tyrosine phosphatase, non-receptor type 8; PTPN22.8; tyrosine-phosphatase; Tyrosine-protein phosphatase non-receptor type 22; unnamed protein product

View more View less

Gene Aliases: 70zpep; LYP; LYP1; LYP2; PEP; PTPN22; PTPN22.5; PTPN22.6; PTPN8

View more View less

UniProt ID: (Human) Q9Y2R2, (Mouse) P29352

View more View less

Entrez Gene ID: (Human) 26191, (Rat) 295338, (Mouse) 19260

View more View less

Function(s)
phosphoprotein phosphatase activity protein tyrosine phosphatase activity non-membrane spanning protein tyrosine phosphatase activity protein binding hydrolase activity phosphatase activity SH3 domain binding kinase binding ubiquitin protein ligase binding molecular_function
Process(es)
immune system process lipid metabolic process autophagy negative regulation of autophagy positive regulation of gene expression negative regulation of gene expression T cell differentiation lipopolysaccharide-mediated signaling pathway positive regulation of type I interferon production response to lipopolysaccharide negative regulation of interleukin-6 production negative regulation of interleukin-8 production negative regulation of tumor necrosis factor production positive regulation of interferon-gamma production regulation of natural killer cell proliferation positive regulation of toll-like receptor 3 signaling pathway positive regulation of toll-like receptor 4 signaling pathway phosphoanandamide dephosphorylation negative regulation of JUN kinase activity regulation of innate immune response T cell receptor signaling pathway regulation of B cell receptor signaling pathway regulation of T cell receptor signaling pathway negative regulation of T cell receptor signaling pathway negative regulation of T cell activation positive regulation of ERK1 and ERK2 cascade negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway cellular response to muramyl dipeptide positive regulation of NLRP3 inflammasome complex assembly regulation of NIK/NF-kappaB signaling positive regulation of protein K63-linked ubiquitination negative regulation of p38MAPK cascade protein dephosphorylation biological_process peptidyl-tyrosine dephosphorylation dephosphorylation
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support