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Invitrogen
PTPN23 Polyclonal Antibody
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FIGURE: 1 / 3
PTPN23 Antibody (PA5-76478) in IHC (P)
Immunohistochemistry analysis of PTPN23 in paraffin-embedded mouse brain. Samples were incubated with PTPN23 polyclonal antibody (Product # PA5-76478) using a dilution of 1:100. Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.
Product Details
PA5-76478
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein of human PTPN23.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Target Information
Plays a role in sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) via its interaction with the ESCRT-I complex (endosomal sorting complex required for transport I), and possibly also other ESCRT complexes. May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: HD-PTP; His domain-containing protein tyrosine phosphatase; Protein tyrosine phosphatase TD14; PTP-TD14; Tyrosine-protein phosphatase non-receptor type 23; unnamed protein product
Gene Aliases: AI462446; HD-PTP; HDPTP; KIAA1471; NEDBASS; PTP-TD14; PTPN23
UniProt ID: (Human) Q9H3S7, (Mouse) Q6PB44
Entrez Gene ID: (Human) 25930, (Mouse) 104831, (Rat) 117552
negative regulation of epithelial cell migration
protein transport
cell projection organization
endocytic recycling
ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
early endosome to late endosome transport
cilium morphogenesis
positive regulation of Wnt protein secretion
positive regulation of homophilic cell adhesion
positive regulation of adherens junction organization
positive regulation of early endosome to late endosome transport
protein dephosphorylation
transport
dephosphorylation
regulation of cell migration
peptidyl-tyrosine dephosphorylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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