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Invitrogen
PTPRM Polyclonal Antibody
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Product Details
PA5-33009
Product Specifications
Species Reactivity
Bovine,
Dog,
Human,
Non-human primate,
Rabbit
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic 16 amino acid peptide from internal region of human PTPRM.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.1% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Percent identity with other species by BLAST analysis: Human, Gorilla, Orangutan, Gibbon, Monkey, Marmoset, Bovine, Dog, Elephant, Panda, Rabbit, Opossum (100%); Mouse, Rat, Bat, Horse (94%); Hamster, Chicken (88%).
For IHC(P), use heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.
Target Information
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP has been shown to mediate cell-cell aggregation through the interaction with another molecule of this PTP on an adjacent cell. This PTP can interact with scaffolding protein RACK1/GNB2L1, which may be necessary for the downstream signaling in response to cell-cell adhesion. Alternative splicing results in multiple transcripts encoding distinct isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: MGC166994; protein tyrosine phosphatase mu; protein tyrosine phosphatase, receptor type, M; protein tyrosine phosphatase, receptor type, mu polypeptide; Protein-tyrosine phosphatase mu; PTP mu; Ptpmu; Receptor-type tyrosine-protein phosphatase mu
Gene Aliases: hR-PTPu; PTPRL1; PTPRM; R-PTP-MU; RPTPM; RPTPU
UniProt ID: (Human) P28827
Entrez Gene ID: (Human) 5797, (Dog) 480203, (Rabbit) 100356969
negative regulation of endothelial cell proliferation
protein dephosphorylation
homophilic cell adhesion via plasma membrane adhesion molecules
signal transduction
negative regulation of endothelial cell migration
retina layer formation
negative regulation of angiogenesis
neuron projection development
retinal ganglion cell axon guidance
peptidyl-tyrosine dephosphorylation
response to drug
positive regulation of vasodilation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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