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Invitrogen
PTPRM Polyclonal Antibody
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Product Details
PA5-33010
Product Specifications
Species Reactivity
Horse,
Hamster,
Human,
Mouse,
Rabbit,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic 18 amino acid peptide from internal region of human PTPRM.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
50 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.1% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Percent identity with other species by BLAST analysis: Human, Gibbon, Monkey, Mouse, Rat, Hamster, Panda, Horse, Rabbit, Opossum (100%); Marmoset, Bovine, Bat (94%).
For IHC(P), use heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.
Target Information
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP has been shown to mediate cell-cell aggregation through the interaction with another molecule of this PTP on an adjacent cell. This PTP can interact with scaffolding protein RACK1/GNB2L1, which may be necessary for the downstream signaling in response to cell-cell adhesion. Alternative splicing results in multiple transcripts encoding distinct isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: MGC166994; protein tyrosine phosphatase mu; protein tyrosine phosphatase receptor-type M; protein tyrosine phosphatase, receptor type, M; protein tyrosine phosphatase, receptor type, mu polypeptide; protein tyrosine phosphatase, receptor-type, M; Protein-tyrosine phosphatase mu; PTP mu; Ptpmu; R-PTP-mu; Receptor-type tyrosine-protein phosphatase mu; unnamed protein product
Gene Aliases: hR-PTPu; I79_010579; Kiaa4044; mKIAA4044; PTPRL1; PTPRM; R-PTP-MU; RPTPM; RPTPmu; RPTPU
UniProt ID: (Human) P28827, (Mouse) P28828
Entrez Gene ID: (Horse) 100059664, (Human) 5797, (Rabbit) 100356969, (Rat) 29616, (Mouse) 19274, (Chinese hamster) 100761852
phosphoprotein phosphatase activity
protein tyrosine phosphatase activity
transmembrane receptor protein tyrosine phosphatase activity
protein binding
hydrolase activity
phosphatase activity
identical protein binding
cadherin binding
extracellular matrix glycoprotein
protein phosphatase
protein modifying enzyme
negative regulation of endothelial cell proliferation
cell adhesion
homophilic cell adhesion via plasma membrane adhesion molecules
signal transduction
response to xenobiotic stimulus
negative regulation of endothelial cell migration
positive regulation of glucose transport
negative regulation of glucose transport
retina layer formation
negative regulation of angiogenesis
negative regulation of cell migration
neuron projection development
retinal ganglion cell axon guidance
glucose transmembrane transport
protein dephosphorylation
peptidyl-tyrosine dephosphorylation
response to drug
positive regulation of vasodilation
dephosphorylation
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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