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Invitrogen
PTPRS Polyclonal Antibody
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FIGURE: 1 / 2
PTPRS Antibody (PA5-100312) in IHC (P)
Immunohistochemistry analysis of PTPRS in human prostate cancer and para-carcinoma tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with PTPRS polyclonal antibody (Product # PA5-100312) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
Product Details
PA5-100312
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human PTPRS(Accession Q13332), corresponding to amino acid residues W447-Y497.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total PTPRS.
Target Information
PTPRS cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycan. Binding to chondroitin sulfate and heparan sulfate proteoglycans has opposite effects on PTPRS oligomerization and regulation of neurite outgrowth. Contributes to the inhibition of neurite and axonal outgrowth by chondroitin sulfate proteoglycans, also after nerve transection. Plays a role in stimulating neurite outgrowth in response to the heparan sulfate proteoglycan GPC2. Required for normal brain development, especially for normal development of the pituitary gland and the olfactory bulb. Functions as tyrosine phosphatase. Mediates dephosphorylation of NTRK1, NTRK2 and NTRK3. Plays a role in down-regulation of signaling cascades that lead to the activation of Akt and MAP kinases. Down-regulates TLR9-mediated activation of NF-kappa-B, as well as production of TNF, interferon alpha and interferon beta.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: LAR-PTP2; Leukocyte common antigen-related protein-tyrosine phosphatase 2; leukocyte common antigen-related proten-tyrosine phosphatase 2; protein tyrosine phosphatase PTPsigma; protein tyrosine phosphatase, receptor type, D; protein tyrosine phosphatase, receptor type, S; PTPNU-3; R-PTP-S; R-PTP-sigma; Receptor-type tyrosine-protein phosphatase S; Receptor-type tyrosine-protein phosphatase sigma; tissue-specific protein tyrosine phosphatase
Gene Aliases: AL022616; Larptp2; PTP; PTP-NU3; PTPNU-3; Ptprd; PTPRS; PTPSIGMA; Ptpsigma.; Ptpt9; R-PTP-S; R-PTP-sigma; Rptpd; RPTPsigma
UniProt ID: (Human) Q13332, (Mouse) B0V2N1, (Rat) Q64605
Entrez Gene ID: (Human) 5802, (Mouse) 19280, (Rat) 25529
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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