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Invitrogen
PTPRS Polyclonal Antibody
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FIGURE: 1 / 2
PTPRS Antibody (PA5-47487) in ICC/IF
Immunocytochemistry analysis of PTPRS in immersion fixed A431 human epithelial carcinoma cell line. Samples were incubated in PTPRS polyclonal antibody (Product # PA5-47487) using a dilution of 10 µg/mL for 3 hours at room temperature followed by NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (red) and counterstained with DAPI(blue). Specific staining was localized to cytoplasm.
Product Details
PA5-47487
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Mouse myeloma cell line NS0-derived recombinant human PTP sigma/PTPRS Glu30-Gly1260
Conjugate
Form
Lyophilized
Concentration
0.2 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody detects the endogenous cleaved extracellular domain of human PTP sigma /PTPRS in Western blots. In Western blots, less than 1% cross-reactivity with recombinant human LAR, PTPR beta, PTPR gamma, PTPR mu, or PTPR kappa is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
PTPRS cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycan. Binding to chondroitin sulfate and heparan sulfate proteoglycans has opposite effects on PTPRS oligomerization and regulation of neurite outgrowth. Contributes to the inhibition of neurite and axonal outgrowth by chondroitin sulfate proteoglycans, also after nerve transection. Plays a role in stimulating neurite outgrowth in response to the heparan sulfate proteoglycan GPC2. Required for normal brain development, especially for normal development of the pituitary gland and the olfactory bulb. Functions as tyrosine phosphatase. Mediates dephosphorylation of NTRK1, NTRK2 and NTRK3. Plays a role in down-regulation of signaling cascades that lead to the activation of Akt and MAP kinases. Down-regulates TLR9-mediated activation of NF-kappa-B, as well as production of TNF, interferon alpha and interferon beta.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: protein tyrosine phosphatase PTPsigma; R-PTP-S; R-PTP-sigma; Receptor-type tyrosine-protein phosphatase S; Receptor-type tyrosine-protein phosphatase sigma
Gene Aliases: PTP-sigma; PTPRS; PTPSIGMA; R-PTP-S; R-PTP-sigma
UniProt ID: (Human) Q13332
Entrez Gene ID: (Human) 5802
protein dephosphorylation
cell adhesion
signal transduction
negative regulation of neuron projection development
spinal cord development
cerebellum development
hippocampus development
cerebral cortex development
corpus callosum development
negative regulation of axon extension
negative regulation of interferon-alpha production
negative regulation of interferon-beta production
negative regulation of toll-like receptor 9 signaling pathway
peptidyl-tyrosine dephosphorylation
negative regulation of collateral sprouting
negative regulation of axon regeneration
modulation of synaptic transmission
synapse organization
negative regulation of dendritic spine development
establishment of endothelial intestinal barrier
regulation of postsynaptic density assembly
trans-synaptic signaling
synaptic membrane adhesion
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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