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Proteintech
PTRF Polyclonal Antibody, CoraLite® Plus 488
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Product Details
CL488-18892
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PTRF fusion protein Ag13486
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 0.5% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: MEDAAALELS SDEAVEVEEV IEESRAERIK RSGLRRVDDF KKAFSKEKME KTKVRTRENL EKTRLKTKEN LEKTRHTLEK RMNKLGTRLV PAERREKLKT SRDKLRKSFT PDHVVYARSK TAVYKVPPFT FHVKKIREGQ VEVLKATEMV EVGADDDEGG AERGEAGDLR RGSSPDVHAL LEITEESDAV LVDKSDSD
Target Information
The polymerase I and transcript release factor (PTRF) enables the dissociation of paused ternary polymerase I transcription complexes from the 3' end of pre-rRNA transcripts, regulating rRNA transcription by promoting the dissociation of transcription complexes and the re-initiation of polymerase I on nascent rRNA transcripts. PTRF also localizes to caveolae at the plasma membrane and is thought to play a critical role in the formation of caveolae and the stabilization of caveolins, translocating from caveolae to the cytoplasm after insulin stimulation. PTRF is also thought to modify lipid metabolism and insulin-regulated gene expression. Mutations in this gene result in a disorder characterized by generalized lipodystrophy and muscular dystrophy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cav-p60; Caveolae-associated protein 1; cavin; Cavin-1; congenital generalized lipodystrophy 4; FLJ90031; Polymerase I and transcript release factor; ptrf; ptrf {ECO:0000312|RGD:1307685}; RNA polymerase I and transcript release factor; TTF-I interacting peptide 12; unnamed protein product
Gene Aliases: 2310075E07Rik; AW546441; Cav-p60; CAVIN; cavin-1; CAVIN1; CGL4; FKSG13; PTRF
UniProt ID: (Human) Q6NZI2, (Mouse) O54724
Entrez Gene ID: (Human) 284119, (Rat) 287710, (Mouse) 19285
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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