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Invitrogen
PTRF Polyclonal Antibody
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Product Details
PA5-110243
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 200-280 of human PTRF (NP_0363642)
Conjugate
Form
Liquid
Concentration
2.48 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: ELSSDEAVEV EEVIEESRAE RIKRSGLRRV DDFKKAFSKE KMEKTKVRTR ENLEKTRLKT KENLEKTRHT LEKRMNKLGT R
Target Information
The polymerase I and transcript release factor (PTRF) enables the dissociation of paused ternary polymerase I transcription complexes from the 3' end of pre-rRNA transcripts, regulating rRNA transcription by promoting the dissociation of transcription complexes and the re-initiation of polymerase I on nascent rRNA transcripts. PTRF also localizes to caveolae at the plasma membrane and is thought to play a critical role in the formation of caveolae and the stabilization of caveolins, translocating from caveolae to the cytoplasm after insulin stimulation. PTRF is also thought to modify lipid metabolism and insulin-regulated gene expression. Mutations in this gene result in a disorder characterized by generalized lipodystrophy and muscular dystrophy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cav-p60; Caveolae-associated protein 1; cavin; Cavin-1; FLJ90031; Polymerase I and transcript release factor; PTRF; ptrf {ECO:0000312|RGD:1307685}; RNA polymerase I and transcript release factor; TTF-I interacting peptide 12
Gene Aliases: 2310075E07Rik; AW546441; Cav-p60; CAVIN; cavin-1; CAVIN1; CGL4; FKSG13; PTRF
UniProt ID: (Human) Q6NZI2, (Mouse) O54724
Entrez Gene ID: (Human) 284119, (Rat) 287710, (Mouse) 19285
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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