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Invitrogen
PUM1 Polyclonal Antibody
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Product Details
PA5-89209
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-130 of human Pumilio 1 (NP_0554911)
Conjugate
Form
Liquid
Concentration
0.88 mg/mL
Amount
88 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: MSVACVLKRK AVLWQDSFSP HLKHHPQEPA NPNMPVVLTS GTGSQAQPQP AANQALAAGT HSSPVPGSIG VAGRSQDDAM VDYFFQRQHG EQLGGGGSGG GGYNNSKHRW PTGDNIHAEH QVRSMDELNH; Positive Samples: HepG2, SH-SY5Y, Mouse liver; Cellular Location: Cytoplasm, Cytoplasmic granule, P-body
Target Information
PUM1 (pumilio homolog 1) is a sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. It is a member of the PUF family comprised of evolutionarily conserved RNA-binding proteins. PUM1 binds to an RNA consensus sequence, the Pumilio Response Element (PRE), and 5'-UGUANAUA-3' that is related to the Nanos Response Element (NRE). PUM1 mediates post-transcriptonal repression of transcripts via different mechanisms - acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation. Mutations to the gene can result in spinocerebellar ataxia 47.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: HsPUM; pumilio 1; Pumilio homolog 1; pumilio-1; RNA binding protein; unnamed protein product
Gene Aliases: AA517475; HSPUM; KIAA0099; mKIAA0099; NEDMSF; PUM1; PUMH; PUMH1; PUML1; Pumm; SCA47
UniProt ID: (Human) Q14671, (Mouse) Q80U78
Entrez Gene ID: (Human) 9698, (Mouse) 80912
regulation of translation
spermatogenesis
adult locomotory behavior
posttranscriptional regulation of gene expression
posttranscriptional gene silencing
cell differentiation
production of miRNAs involved in gene silencing by miRNA
regulation of mRNA stability
stem cell differentiation
regulation of cell cycle
regulation of chromosome segregation
regulation of gene silencing by miRNA
mRNA destabilization
3'-UTR-mediated mRNA destabilization
positive regulation of RIG-I signaling pathway
positive regulation of gene silencing by miRNA
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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