This target displays homology in the following species: Cow: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 78%; Zebrafish: 100%
This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans. Thus, it is implicated in the control of both DNA replication and transcription. Deletion of this gene has been associated with myelodysplastic syndrome and acute myelogenous leukemia.
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Protein Aliases: purine-rich element binding protein B; Purine-rich element-binding protein B; Transcriptional activator protein Pur-beta
Gene Aliases: PURB; PURBETA
UniProt ID: (Human) Q96QR8
Entrez Gene ID: (Human) 5814
Molecular Function: DNA-binding transcription factor