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| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:500-1:1,000 | - |
Immunocytochemistry (ICC/IF) |
1:10-1:100 | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Mouse, Rat |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
PUS1 Fusion Protein Ag2071 (128-427 aa encoded by BC019320) |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.2 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.1% sodium azide |
Storage conditions |
-20°C |
Immunogen sequence: ENHGEDMRK MSFQRCARTD KGVSAAGQVV SLKVWLIDDI LEKINSHLPS HIRILGLKRV TGGFNSKNRC DARTYCYLLP TFAFAHKDRD VQDETYRLSA ETLQQVNRLL ACYKGTHNFH NFTSQKGPQD PSACRYILEM YCEEPFVREG LEFAVIRVKG QSFMMHQIRK MVGLVVAIVK GYAPESVLER SWGTEKVDVP KAPGLGLVLE RVHFEKYNQR FGNDGLHEPL DWAQEEGKVA AFKEEHIYPT IIGTERDERS MAQWLSTLPI HNFSATALTA GGTGAKVPSP LEGSEGDGDT D (128-427 aa encoded by BC019320)
The PRKDC gene encodes the catalytic subunit of a nuclear DNA-dependent serine/threonine protein kinase (DNA-PK). The second component is the autoimmune antigen Ku, which is encoded by the G22P1 gene on chromosome 22q. On its own, the catalytic subunit of DNA-PK is inactive and relies on the G22P1 component to direct it to the DNA and trigger its kinase activity; PRKDC must be bound to DNA to express its catalytic properties.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: mitochondrial tRNA pseudouridine synthase A; pseudouridine synthase 1; pus1 {ECO:0000312|RGD:1311871}; tRNA pseudouridine synthase A; tRNA pseudouridine synthase A, mitochondrial; tRNA pseudouridine(38-40) synthase; tRNA pseudouridylate synthase I; tRNA uridine isomerase I; tRNA-uridine isomerase I
Gene Aliases: A730013B20Rik; MLASA1; MNCb-0873; MPUS1; mPus1p; PP8985; PUS1
UniProt ID: (Human) Q9Y606, (Rat) Q4KM92, (Mouse) Q9WU56
Entrez Gene ID: (Human) 80324, (Rat) 304567, (Mouse) 56361
Molecular Function:
lyase
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