This target displays homology in the following species: Mouse: 100%; Rat: 100%
The PRKDC gene encodes the catalytic subunit of a nuclear DNA-dependent serine/threonine protein kinase (DNA-PK). The second component is the autoimmune antigen Ku, which is encoded by the G22P1 gene on chromosome 22q. On its own, the catalytic subunit of DNA-PK is inactive and relies on the G22P1 component to direct it to the DNA and trigger its kinase activity; PRKDC must be bound to DNA to express its catalytic properties.
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Protein Aliases: tRNA pseudouridine synthase A; tRNA pseudouridine synthase A, mitochondrial; tRNA pseudouridine(38-40) synthase; tRNA pseudouridylate synthase I; tRNA-uridine isomerase I
Gene Aliases: A730013B20Rik; MNCb-0873; MPUS1; mPus1p; Pus1
UniProt ID: (Mouse) Q9WU56
Entrez Gene ID: (Mouse) 56361
Molecular Function: lyase