Keep as concentrated solution.
Predicted reactivity: Mouse (93%), Rat (93%), Sheep (87%).
Positive Control: 293T, A431, H1299, HeLa, HepG2, Molt-4, Raji, mouse brain.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
The PRKDC gene encodes the catalytic subunit of a nuclear DNA-dependent serine/threonine protein kinase (DNA-PK). The second component is the autoimmune antigen Ku, which is encoded by the G22P1 gene on chromosome 22q. On its own, the catalytic subunit of DNA-PK is inactive and relies on the G22P1 component to direct it to the DNA and trigger its kinase activity; PRKDC must be bound to DNA to express its catalytic properties.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: mitochondrial tRNA pseudouridine synthase A; tRNA pseudouridine synthase A; tRNA pseudouridine synthase A, mitochondrial; tRNA pseudouridine(38-40) synthase; tRNA pseudouridylate synthase I; tRNA uridine isomerase I; tRNA-uridine isomerase I
Gene Aliases: A730013B20Rik; MLASA1; MNCb-0873; MPUS1; mPus1p; PP8985; PUS1
Molecular Function: lyase