The antibody detects endogenous levels of total PUS10 protein.
Pseudouridylate synthases catalyze pseudouridination of structural RNAs, including transfer, ribosomal, and splicing RNAs. PUS10 catalyzes the formation of the universal psi55 in the GC loop of transfer RNAs (Probable). Modulator of TRAIL-induced cell death via activation of procaspase 8 and BID cleavage. Required for the progression of the apoptotic signal through intrinsic mitochondrial cell death.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CCDC139; coiled-coil domain containing 139; Coiled-coil domain-containing protein 139; DOBI; pseudouridine synthase 10; Psi55 synthase; Putative tRNA pseudouridine synthase Pus10; tRNA pseudouridine 55 synthase; tRNA pseudouridylate synthase; tRNA-uridine isomerase
Gene Aliases: 2810013G11Rik; 4933435A13Rik; AU014648; C77560; CCDC139; DOBI; PUS10