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Product Details
24713-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Not Applicable
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PVRL1 Fusion Protein Ag20074 (31-334 aa encoded by BC104948)
Conjugate
Form
Liquid
Concentration
0.27 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: QVVQVNDSM YGFIGTDVVL HCSFANPLPS VKITQVTWQK STNGSKQNVA IYNPSMGVSV LAPYRERVEF LRPSFTDGTI RLSRLELEDE GVYICEFATF PTGNRESQLN LTVMAKPTNW IEGTQAVLRA KKGQDDKVLV ATCTSANGKP PSVVSWETRL KGEAEYQEIR NPNGTVTVIS RYRLVPSREA HQQSLACIVN YHMDRFKESL TLNVQYEPEV TIEGFDGNWY LQRMDVKLTC KADANPPATE YHWTTLNGSL PKGVEAQNRT LFFKGPINYS LAGTYICEAT NPIGTRSGQV EVNIT (31-334 aa encoded by B C104948)
Target Information
This gene encodes an adhesion protein that plays a role in the organization of adherens junctions and tight junctions in epithelial and endothelial cells. The protein is a calcium(2+)-independent cell-cell adhesion molecule that belongs to the immunoglobulin superfamily and has 3 extracellular immunoglobulin-like loops, a single transmembrane domain, and a cytoplasmic region. This protein acts as a receptor for glycoprotein D of herpes simplex viruses 1 and 2, and pseudorabies virus and mediates viral entry into epithelial and neuronal cells. Mutations in this gene cause cleft lip and palate/ectodermal dysplasia 1 syndrome as well as non-syndromic cleft lip with or without cleft palate. Alternative splicing results in multiple transcript variants encoding proteins with distinct C-termini.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CD111; ectodermal dysplasia 4 (Margarita Island type); herpes simplex virus type 1 sensitivity; Herpes virus entry mediator C; Herpesvirus entry mediator C; Herpesvirus Ig-like receptor; HIgR; nectin 1; Nectin cell adhesion molecule 1; Nectin-1; nectin-1 alpha; nectin-1 delta; poliovirus receptor-like 1; poliovirus receptor-related 1 (herpesvirus entry mediator C); Poliovirus receptor-related protein 1
Gene Aliases: AI835281; AW549174; CD111; CLPED1; ED4; HIgR; HV1S; HVEC; nectin-1; NECTIN1; OFC7; PRR; PRR1; PVRL1; PVRR; PVRR1; SK-12
UniProt ID: (Human) Q15223, (Mouse) Q9JKF6
Entrez Gene ID: (Human) 5818, (Mouse) 58235
lens morphogenesis in camera-type eye
desmosome organization
iron ion transport
cell adhesion
homophilic cell adhesion via plasma membrane adhesion molecules
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
axon guidance
viral process
single organismal cell-cell adhesion
viral entry into host cell
camera-type eye morphogenesis
regulation of synapse assembly
retina development in camera-type eye
enamel mineralization
immune response
signal transduction
cell recognition
adherens junction organization
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