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Product Details
PA5-59927
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human PYGO1. Recombinant protein control fragment (Product #RP-89401).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2646169
Product Specific Information
Immunogen sequence: RMPPHVPPRM SSPYCGPYSL RNQPHPFPQN PLGMGFNRPH AFNFGPHDNS SFGNPSYNNA LSQNVNMPNQ HFRQNPAENF SQIPPQNASQ VSNPDLASNF VPGNNSNFTS PLESNHSFIP PPNTFGQAKA PPPKQDFTQG ATK
Highest antigen sequence identity to the following orthologs: Mouse - 90%, Rat - 88%.
Target Information
Pygopus 1 (PYGO1) is a gene located on chromosome 6p21.31, encoding a protein that plays a crucial role in the Wnt signaling pathway, which is fundamental for various developmental processes including cell proliferation, polarity, and fate determination. PYGO1 is a part of the Pygopus family of proteins, characterized by their Plant Homeodomain (PHD) finger domain that facilitates interaction with histones. Within the Wnt signaling pathway, PYGO1 acts as a coactivator by binding to components of the transcription complex, thus aiding in the expression of Wnt target genes. The protein is especially important in embryonic development and is implicated in specific processes such as limb formation and neural development. Dysregulation of PYGO1 and the Wnt pathway is associated with developmental disorders and certain cancers, demonstrating the protein's significance in maintaining cellular homeostasis. Current studies are focusing on the mechanistic aspects of PYGO1's function in transcription regulation and its potential role in therapeutic strategies targeting Wnt signaling-related diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Pygopus homolog 1; pygopus-like protein 1
Gene Aliases: PYGO1
UniProt ID: (Human) Q9Y3Y4
Entrez Gene ID: (Human) 26108
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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