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Proteintech
PYGO2 Polyclonal Antibody
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Product Details
11555-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PYGO2 Fusion Protein Ag2111 (101-406 aa encoded by BC032099)
Conjugate
Form
Liquid
Concentration
0.28 mg/mL
Amount
42 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: FGGFRVQGG MAGQVPPGYS TGGGGGPQPL RRQPPPFPPN PMGPAFNMPP QGPGYPPPGN MNFPSQPFNQ PLGQNFSPPS GQMMPGPVGG FGPMISPTMG QPPRAELGPP SLSQRFAQPG APFGPSPLQR PGQGLPSLPP NTSPFPGPDP GFPGPGGEDG GKPLNPPAST AFPQEPHSGS PAAAVNGNQP SFPPNSSGRG GGTPDANSLA PPGKAGGGSG PQPPPGLVYP CGACRSEVND DQDAILCEAS CQKWFHRECT GMTESAYGLL TTEASAVWAC DLCLKTKEIQ SVYIREGMGQ LVAANDG (101-406 aa encoded by BC032099 )
Target Information
The PYGO2 gene encodes pygopus family PHD finger 2, a key component of the Wnt signaling pathway, which is critical for embryonic development, cell proliferation, and differentiation. PYGO2 operates as a chromatin remodeling factor, interacting with the beta-catenin-LEF/TCF transcriptional complex, facilitating the transcription of Wnt target genes by recruiting chromatin-modifying enzymes. This activity is vital for maintaining the balance between stem cell renewal and differentiation in various tissues, including the brain and the skin. Additionally, PYGO2 plays significant roles in spermatogenesis and hematopoiesis by modulating gene expression necessary for these processes. Dysregulation of PYGO2 expression can lead to developmental abnormalities and is often implicated in cancer progression, indicating its potential as a biomarker for tumorigenic stem cell-like properties and metastatic behavior. Research continues to explore PYGO2's mechanisms and interactions to understand its contributions to development and its implications in disease states, particularly in cancer biology.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: mpygo2; nuclear; pygopus 2; Pygopus homolog 2; unnamed protein product
Gene Aliases: 1190004M21Rik; PP7910; PYGO2; RGD1308535
UniProt ID: (Human) Q9BRQ0
Entrez Gene ID: (Human) 90780, (Rat) 295251, (Mouse) 68911
kidney development
lens development in camera-type eye
spermatid development
spermatid nucleus differentiation
brain development
Wnt signaling pathway
mammary gland development
regulation of mammary gland epithelial cell proliferation
developmental growth
palate development
canonical Wnt signaling pathway
in utero embryonic development
post-embryonic development
regulation of histone acetylation
positive regulation of chromatin binding
regulation of catalytic activity
regulation of histone H3-K4 methylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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