Recommended positive controls: NIH-3T3, A549, H1299, HCT116, Huh7.
Predicted reactivity: Human (98%), Mouse (100%), Rat (100%), Pig (98%), Bovine (98%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
The zinc transporter ZIP14, also known as SLC39A14, is a member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. The zinc transporter family is divided into four subfamilies (I, II, LIV-1 and gufA). ZIP14 is a glycosylated multipass plasma membrane protein that belongs to the ZIP transporter subfamily LIV-1. ZIP14 has been shown to contribute to the hypozincemia of inflammation and infection and is regulated in the liver by IL-6. In addition to zinc, ZIP14 is also involved in the cellular uptake of non-transferrin-bound iron as well as iron bound to transferrin.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: mpygo2; pygopus 2; Pygopus homolog 2
Gene Aliases: 1190004M21Rik; PP7910; PYGO2
UniProt ID: (Human) Q9BRQ0