Keep as concentrated solution.
Positive Control: A431, HeLa, mouse brain, rat brain.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
PYK2 encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CADTK; CADTK Antibody; CAK beta; CAK-beta; CAKB Antibody; Calcium-dependent tyrosine kinase; Calcium-regulated non-receptor proline-rich tyrosine kinase; Cell adhesion kinase beta; cellular adhesion kinase beta; FADK 2; FADK2 Antibody; FAK2 Antibody; Focal adhesion kinase 2; PKB Antibody; Proline-rich tyrosine kinase 2; protein kinase B; protein tyrosine kinase 2 beta; protein tyrosine kinase 2 beta Antibody; Protein-tyrosine kinase 2-beta; PTK Antibody; PTK2 protein tyrosine kinase 2 beta; PTK2B Antibody; PTK2B protein tyrosine kinase 2 beta; RAFTK; RAFTK Antibody; Related adhesion focal tyrosine kinase
Gene Aliases: CADTK; CAKB; CAKbeta; E430023O05Rik; FADK2; FAK2; PKB; PTK; PTK2B; PYK2; RAFTK