Synthetic peptide sequence: YPIKPEAPREDASPEELNRYYASLRHYLNLVTRQRY.
Reconstitution information: Add 0.2 mL of distilled water will yield a concentration of 500 µg/mL.
Peptide tyrosine-tyrosine amide (3-36), or PYY (3-36), is a major metabolite of the gut hormone PYY and is produced by the action of dipeptidyl peptidase IV on PYY in the intestinal brush border and in the circulation. PYY (3-36) is a potent inhibitor of food intake in rats and humans, acting selectively on the Y2 receptor to inhibit orexigenic NPY neurons in the arcuate nucleus, thus disinhibiting anorexigenic POMC neurons. The anorexigenic effect of PYY (3-36) is additive to that of the co-secreted gut hormone GLP-1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Peptide tyrosine tyrosine; peptide tyrosine-tyrosine (YY); Peptide YY; Peptide YY(3-36); prepro-PYY; PYY; PYY-I; PYY-II
Gene Aliases: GHYY; peptide-YY; PYY; PYY-I; PYY1; RATGHYY; Yy