This antibody, generated against the fragment 999-1383 aa of palladin, recognizes most isoforms of this protein, except isoform 6.
Palladin is a cytoskeletal protein required for organization of normal actin cytoskeleton. Palladin plays roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. Palladin may function as a scaffolding molecule with the potential to impact both actin polymerization as well as the assembly of existing actin filaments into higher-order arrays. It binds to proteins that bind to either monomeric or filamentous actin. It localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles. Palladin's different isoforms may have functional differences. It is also involved in the control of morphological and cytoskeletal changes associated with dendritic cell maturation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 90kDa actin-associated protein palladin; FLJ22190; FLJ38193; FLJ39139; myoneurin; Palladin; palladin isoform; Sarcoma antigen NY-SAR-77; SIH002
Gene Aliases: 2410003B16Rik; 6030492A02; CGI-151; CGI151; KIAA0992; MYN; PALLD; PNCA1; SIH002
Molecular Function: cell adhesion molecule cytokine receptor defense/immunity protein hydrolase immunoglobulin receptor superfamily immunoglobulin superfamily cell adhesion molecule phosphatase protein phosphatase receptor