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Invitrogen

Pan Ras Polyclonal Antibody

View all (11) Pan Ras antibodies

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Pan Ras Polyclonal Antibody

Product Details

PA5-104464

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:3,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:100-1:300
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human NRAS(Accession P01111), corresponding to amino acid residues V7-D57.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2853765

Product Specific Information

Antibody detects endogenous levels of total RASH/RASK/RASN.

Target Information

This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, mental retardation, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: c-H-ras; c-Ha-ras p21 protein; c-Ha-ras transgene; c-has/bas p21 protein; c-K-ras; c-K-ras2 protein; c-Ki-ras; c-Kirsten-ras protein; c-Kirsten-ras proto-oncogene; c-ras-Ki-2 protein; cellular c-Ki-ras2; cellular c-Ki-ras2 proto-oncogene; cellular transforming proto-oncogene; GTP- and GDP-binding peptide B; GTPase HRas; GTPase Hras1; GTPase KRas; GTPase NRas; H-ras 1 protein; H-Ras-1; Ha-Ras; Ha-Ras1 proto-oncoprotein; Harvey ras1 protein; Harvey rat sarcoma viral (v-Ha-ras) oncogene homolog; Harvey rat sarcoma viral oncogene homolog; Harvey rat sarcoma viral oncoprotein; Harvey rat sarcoma virus oncogene 1; HRAS; K RAS; K-Ras 2; K-ras p21 protein; Ki-Ras; Kirsten rat sarcoma oncogene 2, expressed; Kirsten rat sarcoma viral oncogene homolog; Kirsten rat sarcoma viral oncogene homologue 2 (active); Kirsten rat sarcoma viral proto-oncogene; KRAS-ENOPH fusion; Kras-Enoph1 fusion protein; N-ras protein part 4; Neuroblastoma RAS; neuroblastoma RAS viral (v-ras) oncogene homolog; neuroblastoma RAS viral oncogene homolog; oncogene KRAS2; p19 H-RasIDX protein; p21 protein; p21ras; PR310 c-K-ras oncogene; PR371 c-K-ras oncogene; proto-oncogene GTPase; Ras family small GTP binding protein H-Ras; RASK; RASN; small GTP binding protein; transformation gene: oncogene HAMSV; Transforming protein N-Ras; Transforming protein p21; unnamed protein product; v-Ha-ras Harvey rat sarcoma viral oncogene homolog; v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog; v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog; v-ras neuroblastoma RAS viral oncogene homolog

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Gene Aliases: 'C-K-RAS; AI929937; ALPS4; AV095280; C-BAS/HAS; C-H-RAS; c-Ha-ras; C-HA-RAS1; C-K-RAS; c-Ki-ras; c-Ki-ras2; c-rasHa; CFC2; CMNS; CTLO; H-ras; H-RASIDX; Ha-ras; HAMSV; Harvey-ras; HRAS; Hras-1; HRAS1; K-Ras; K-Ras 2; K-RAS2A; K-RAS2B; K-RAS4A; K-RAS4B; KI-RAS; KRAS; Kras-2; KRAS1; KRAS2; N-ras; NCMS; NRAS; NRAS1; NS; NS3; NS6; OES; p21; p21B; p21ras; RALD; RALD1; RALD2; ras; RASH1; RASK2

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UniProt ID: (Mouse) Q61411, (Rat) P20171, (Rat) P08644, (Mouse) P32883, (Rat) Q04970

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Entrez Gene ID: (Human) 3265, (Mouse) 15461, (Rat) 293621, (Human) 3845, (Rat) 24525, (Mouse) 16653, (Human) 4893, (Mouse) 18176, (Rat) 24605

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Function(s)
GTPase activity obsolete small monomeric GTPase activity protein binding GTP binding GDP binding protein anchor phospholipase C activator activity nucleotide binding protein C-terminus binding GMP binding LRR domain binding identical protein binding macromolecular complex binding protein complex binding molecular_function small GTPase
Process(es)
MAPK cascade regulation of transcription from RNA polymerase II promoter chemotaxis signal transduction cell surface receptor signaling pathway Ras protein signal transduction positive regulation of cell proliferation negative regulation of cell proliferation insulin receptor signaling pathway organ morphogenesis negative regulation of gene expression Schwann cell development positive regulation of cell migration regulation of actin cytoskeleton organization regulation of cell proliferation myelination positive regulation of MAPK cascade positive regulation of transcription from RNA polymerase II promoter positive regulation of JNK cascade positive regulation of Ras protein signal transduction positive regulation of epithelial cell proliferation regulation of cell cycle adipose tissue development positive regulation of ERK1 and ERK2 cascade cellular response to gamma radiation positive regulation of wound healing positive regulation of protein targeting to membrane cellular senescence regulation of neurotransmitter receptor localization to postsynaptic specialization membrane positive regulation of ruffle assembly positive regulation of miRNA metabolic process positive regulation of protein phosphorylation endocytosis apoptotic process cell cycle arrest mitotic cell cycle checkpoint small GTPase mediated signal transduction cell aging cell proliferation positive regulation of gene expression negative regulation of GTPase activity positive regulation of MAP kinase activity negative regulation of neuron apoptotic process positive regulation of GTPase activity positive regulation of DNA replication regulation of long-term neuronal synaptic plasticity protein heterooligomerization intrinsic apoptotic signaling pathway positive regulation of actin cytoskeleton reorganization visual learning actin cytoskeleton organization regulation of synaptic transmission, GABAergic positive regulation of Rac protein signal transduction social behavior negative regulation of cell differentiation striated muscle cell differentiation epithelial tube branching involved in lung morphogenesis liver development I-kappaB kinase/NF-kappaB signaling female pregnancy response to gravity cytokine-mediated signaling pathway positive regulation of TOR signaling response to isolation stress negative regulation of programmed cell death response to glucocorticoid response to mineralocorticoid myoblast proliferation cardiac muscle cell proliferation positive regulation of cellular senescence homeostasis of number of cells within a tissue positive regulation of nitric-oxide synthase activity positive regulation of NF-kappaB transcription factor activity positive regulation of endothelial cell proliferation regulation of protein phosphorylation regulation of gene expression positive regulation of fibroblast proliferation negative regulation of skeletal muscle tissue development establishment of protein localization to Golgi biological_process
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