Search

  • Order Status
  • Quick Order
  • Promos

Invitrogen

Pan Ras Recombinant Rabbit Monoclonal Antibody (6S6F3)

View all (16) Pan Ras antibodies

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Certificates
Protocols
Questions & Answers
Datasheet
Certificates
Protocols
Questions & Answers
Datasheet
Certificates
Protocols
Questions & Answers
Additional Information:
{{banner.description}}
{{$ctrl.isSkuNotesCollapsed ? 'View more' : 'View less'}}
Pan Ras Recombinant Rabbit Monoclonal Antibody (6S6F3)

Product Details

MA5-35567

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:10,000
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

6S6F3

Immunogen

Synthetic peptide
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.3 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol, 0.05% BSA

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2849467

Product Specific Information

Immunogen sequence: MTEYKLVVVG AGGVGKSALT IQLIQNHFVD EYDPTIEDSY RKQVVIDGET CLLDILDTAG QEEYSAMRDQ YMRTGEGFLC VFAINNSKSF ADINLYREQI

Target Information

This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, mental retardation, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: c-H-ras; c-Ha-ras p21 protein; c-Ha-ras transgene; c-has/bas p21 protein; c-K-ras; c-K-ras2 protein; c-Ki-ras; c-Kirsten-ras protein; c-Kirsten-ras proto-oncogene; c-ras-Ki-2 protein; cellular c-Ki-ras2; cellular c-Ki-ras2 proto-oncogene; cellular transforming proto-oncogene; GTP- and GDP-binding peptide B; GTPase HRas; GTPase Hras1; GTPase KRas; GTPase NRas; H-ras 1 protein; H-Ras-1; Ha-Ras; Ha-Ras1 proto-oncoprotein; Harvey ras1 protein; Harvey rat sarcoma viral (v-Ha-ras) oncogene homolog; Harvey rat sarcoma viral oncogene homolog; Harvey rat sarcoma viral oncoprotein; Harvey rat sarcoma virus oncogene 1; HRAS; K RAS; K-Ras 2; K-ras p21 protein; Ki-Ras; Kirsten rat sarcoma oncogene 2, expressed; Kirsten rat sarcoma viral oncogene homolog; Kirsten rat sarcoma viral oncogene homologue 2 (active); Kirsten rat sarcoma viral proto-oncogene; KRAS-ENOPH fusion; Kras-Enoph1 fusion protein; N-ras protein part 4; Neuroblastoma RAS; neuroblastoma RAS viral (v-ras) oncogene homolog; neuroblastoma RAS viral oncogene homolog; oncogene KRAS2; p19 H-RasIDX protein; p21 protein; p21ras; PR310 c-K-ras oncogene; PR371 c-K-ras oncogene; proto-oncogene GTPase; Ras family small GTP binding protein H-Ras; RASK; RASN; small GTP binding protein; transformation gene: oncogene HAMSV; Transforming protein N-Ras; Transforming protein p21; unnamed protein product; v-Ha-ras Harvey rat sarcoma viral oncogene homolog; v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog; v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog; v-ras neuroblastoma RAS viral oncogene homolog

View more View less

Gene Aliases: 'C-K-RAS; AI929937; ALPS4; AV095280; C-BAS/HAS; C-H-RAS; c-Ha-ras; C-HA-RAS1; C-K-RAS; c-Ki-ras; c-Ki-ras2; c-rasHa; CFC2; CMNS; CTLO; H-ras; H-RASIDX; Ha-ras; HAMSV; Harvey-ras; HRAS; Hras-1; HRAS1; K-Ras; K-Ras 2; K-RAS2A; K-RAS2B; K-RAS4A; K-RAS4B; KI-RAS; KRAS; Kras-2; KRAS1; KRAS2; N-ras; NCMS; NRAS; NRAS1; NS; NS3; NS6; OES; p21; p21B; p21ras; RALD; ras; RASH1; RASK2

View more View less

UniProt ID: (Human) P01112, (Mouse) Q61411, (Rat) P20171, (Human) P01116, (Rat) P08644, (Mouse) P32883, (Human) P01111, (Rat) Q04970

View more View less

Entrez Gene ID: (Human) 3265, (Mouse) 15461, (Rat) 293621, (Human) 3845, (Rat) 24525, (Mouse) 16653, (Human) 4893, (Mouse) 18176, (Rat) 24605

View more View less

Function(s)
nucleotide binding GTPase activity obsolete small monomeric GTPase activity protein binding GTP binding hydrolase activity GDP binding protein anchor phospholipase C activator activity protein C-terminus binding GMP binding LRR domain binding identical protein binding macromolecular complex binding protein complex binding molecular_function small GTPase
Process(es)
MAPK cascade regulation of transcription from RNA polymerase II promoter endocytosis chemotaxis signal transduction cell surface receptor signaling pathway small GTPase mediated signal transduction Ras protein signal transduction positive regulation of cell proliferation negative regulation of cell proliferation insulin receptor signaling pathway organ morphogenesis positive regulation of gene expression negative regulation of gene expression Schwann cell development positive regulation of cell migration positive regulation of interferon-gamma production regulation of actin cytoskeleton organization T-helper 1 type immune response regulation of cell proliferation myelination defense response to protozoan positive regulation of MAPK cascade negative regulation of neuron apoptotic process positive regulation of transcription from RNA polymerase II promoter positive regulation of JNK cascade fibroblast proliferation positive regulation of fibroblast proliferation regulation of long-term neuronal synaptic plasticity positive regulation of epithelial cell proliferation T cell receptor signaling pathway neuron apoptotic process regulation of cell cycle adipose tissue development positive regulation of ERK1 and ERK2 cascade cellular response to gamma radiation positive regulation of wound healing positive regulation of protein targeting to membrane cellular senescence oncogene-induced cell senescence intrinsic apoptotic signaling pathway regulation of neurotransmitter receptor localization to postsynaptic specialization membrane positive regulation of ruffle assembly positive regulation of miRNA metabolic process positive regulation of protein phosphorylation apoptotic process cell cycle arrest mitotic cell cycle checkpoint cell aging cell proliferation negative regulation of GTPase activity positive regulation of MAP kinase activity positive regulation of GTPase activity positive regulation of DNA replication positive regulation of Ras protein signal transduction protein heterooligomerization positive regulation of actin cytoskeleton reorganization visual learning actin cytoskeleton organization regulation of synaptic transmission, GABAergic positive regulation of Rac protein signal transduction social behavior negative regulation of cell differentiation striated muscle cell differentiation epithelial tube branching involved in lung morphogenesis liver development female pregnancy response to gravity gene expression glial cell proliferation Rac protein signal transduction cytokine-mediated signaling pathway forebrain astrocyte development negative regulation of epithelial cell differentiation response to isolation stress skeletal muscle cell differentiation homeostasis of number of cells within a tissue response to glucocorticoid response to mineralocorticoid myoblast proliferation cardiac muscle cell proliferation positive regulation of glial cell proliferation Type I pneumocyte differentiation positive regulation of cellular senescence positive regulation of nitric-oxide synthase activity positive regulation of NF-kappaB transcription factor activity positive regulation of endothelial cell proliferation regulation of protein phosphorylation regulation of gene expression negative regulation of skeletal muscle tissue development establishment of protein localization to Golgi biological_process
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support