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Invitrogen

Pan-cadherin Monoclonal Antibody (R.976.9)

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View all (16) Pan-cadherin antibodies

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Product Details

MA5-15036

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
View 1 publication 1 publication
Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Rat

Host/Isotype

Rabbit / IgG

Class

Monoclonal

Type

Antibody

Clone

R.976.9

Immunogen

Synthetic peptide corresponding to a conserved region of human N-, R-, E- and P-Cadherin

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 µg/mL

Amount

0.1 µg

Purification

Affinity chromatography

Storage buffer

0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol

Contains

<0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_10984067

Product Specific Information

It is not recommended to aliquot this antibody.

Target Information

Pan Cadherin including CDH1, CDH2, CDH3, CDH4 protein belong to a family of transmembrane molecules that mediate calcium-dependent intercellular adhesion. Cadherins are involved in controlling morphogenetic movements during development and regulate cell surface adhesion through homotypic adhesion with the same cadherin species. N-cadherin's function is dependent on its association with the actin-cytoskeleton and is mediated through interactions between the C-terminal region of N-cadherin and the cytoplasmic catenin proteins. The stability of this association is regulated by phosphorylation and dephosphorylation of beta-catenin.This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. The protein functions during gastrulation and is required for establishment of left-right asymmetry. At certain central nervous system synapses, presynaptic to postsynaptic adhesion is mediated at least in part by this gene product.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: ARC-1; cadherin 1, E-cadherin (epithelial); cadherin 1, type 1, E-cadherin (epithelial); cadherin 2 type 1 N-cadherin (neuronal); cadherin 2, type 1, N-cadherin (neuronal); cadherin 3, type 1, P-cadherin (placental); cadherin 4 type 1 R-cadherin (retinal); cadherin 4, type 1, preproprotein; cadherin 4, type 1, R-cadherin (retinal); cadherin e; Cadherin-1; Cadherin-2; Cadherin-3; Cadherin-4; cadherin-E; Cadherin-N; calcium-dependent adhesion protein, epithelial; calcium-dependent adhesion protein, neuronal; calcium-dependent adhesion protein, placental; CAM 120/80; CD324; CD325; CDw325; CDw325 antigen; cell-CAM 120/80; E-cadherin; E-cadherin 1; epididymis secretory sperm binding protein; Epithelial cadherin; N-cadherin; N-cadherin 1; Neural cadherin; Neural-cadherin; P-cadherin; Pan Cadherin; Placental cadherin; Placental-cadherin; R-CAD; R-cadherin; retina cadherin; Retinal cadherin; RPE-specific cadherin; unnamed protein product; Uvomorulin

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Gene Aliases: AA960649; ACOGS; ADHD8; AI385538; Arc-1; ARVD14; AW120700; BCDS1; CAD4; Cadp; CD324; CD325; CDH1; CDH2; CDH3; CDH4; Cdh4l; CDHE; CDHN; CDHP; CDw325; E-cad; ECAD; HJMD; L-CAM; LCAM; N-cadherin; NCAD; P-cadherin; PCAD; R-CAD; R-Cadh; R-cadherin; RCAD; Um; UVO

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UniProt ID: (Human) P12830, (Human) P19022, (Human) P22223, (Human) P55283, (Mouse) P09803, (Rat) Q9R0T4, (Mouse) P15116, (Rat) Q9Z1Y3, (Mouse) P10287, (Mouse) P39038

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Entrez Gene ID: (Human) 999, (Human) 1000, (Human) 1001, (Human) 1002, (Mouse) 12550, (Rat) 83502, (Mouse) 12558, (Rat) 83501, (Rat) 116777, (Mouse) 12560, (Mouse) 12561, (Rat) 114588

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Function(s)
calcium ion binding protein binding beta-catenin binding ankyrin binding GTPase activating protein binding identical protein binding gamma-catenin binding cadherin binding metal ion binding cell adhesion molecule binding protein binding involved in cell-cell adhesion protein tyrosine kinase binding RNA binding enzyme binding protein kinase binding protein phosphatase binding alpha-catenin binding glycoprotein binding protein domain specific binding protein complex binding nitric-oxide synthase binding molecular_function cadherin
Process(es)
cell morphogenesis desmosome assembly cell-cell junction assembly cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules synapse assembly response to xenobiotic stimulus response to toxic substance regulation of gene expression calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules cell migration pituitary gland development negative regulation of cell-cell adhesion negative regulation of cell migration negative regulation of axon extension neuron projection development cell junction assembly adherens junction organization positive regulation of protein import into nucleus cell-cell adhesion mediated by cadherin positive regulation of transcription, DNA-templated regulation of transport cellular response to lithium ion response to heparin cellular response to indole-3-methanol protein localization to plasma membrane cell-cell adhesion regulation of protein catabolic process at postsynapse, modulating synaptic transmission response to Gram-positive bacterium positive regulation of cellular protein localization type B pancreatic cell development heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules glial cell differentiation neural crest cell development telencephalon development cerebral cortex development detection of muscle stretch positive regulation of MAPK cascade blood vessel morphogenesis brain morphogenesis homeostasis of number of cells striated muscle cell differentiation radial glial cell differentiation neuroepithelial cell differentiation regulation of oligodendrocyte progenitor proliferation negative regulation of canonical Wnt signaling pathway mesenchymal cell migration synaptic vesicle clustering neuroligin clustering involved in postsynaptic membrane assembly neuronal stem cell population maintenance regulation of postsynaptic density protein 95 clustering positive regulation of synaptic vesicle clustering retina homeostasis visual perception positive regulation of gene expression positive regulation of keratinocyte proliferation hair cycle process negative regulation of transforming growth factor beta receptor signaling pathway keratinization positive regulation of monophenol monooxygenase activity positive regulation of insulin-like growth factor receptor signaling pathway positive regulation of melanin biosynthetic process negative regulation of catagen positive regulation of canonical Wnt signaling pathway positive regulation of melanosome transport axon guidance positive regulation of axon extension axon extension in utero embryonic development trophectodermal cell differentiation epithelial cell morphogenesis sensory perception of sound single organismal cell-cell adhesion protein metabolic process regulation of protein localization regulation of water loss via skin positive regulation of transcription factor import into nucleus regulation of cysteine-type endopeptidase activity involved in apoptotic process regulation of epithelial cell proliferation negative regulation of epithelial cell proliferation protein homooligomerization intestinal epithelial cell development salivary gland cavitation regulation of branching involved in salivary gland morphogenesis bicellular tight junction assembly cellular response to amino acid stimulus establishment of protein localization to plasma membrane cochlea development regulation of protein localization to cell surface regulation of neuron migration response to organic substance response to drug regulation of signal transduction regulation of myelination regulation of Rho protein signal transduction regulation of axonogenesis protein heterooligomerization negative regulation of transforming growth factor beta2 production wound healing canonical Wnt signaling pathway regulation of hair cycle by canonical Wnt signaling pathway
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