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Bioss
Patched Polyclonal Antibody
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FIGURE: 1 / 1
Patched Antibody (BS-24459R) in WB
Lane 1:Mouse Cerebrum tissue lysates; Lane 2: Rat Cerebrum tissue lysates probed with Patched Polyclonal Antibody, Unconjugated (bs-24459R) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at 1:20000 for 60 min at 37°C.
Product Details
BS-24459R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human Patched (1-100).
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.03% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
This gene encodes a member of the patched gene family. The encoded protein is the receptor for sonic hedgehog, a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis, as well as the desert hedgehog and indian hedgehog proteins. This gene functions as a tumor suppressor. Mutations of this gene have been associated with basal cell nevus syndrome, esophageal squamous cell carcinoma, trichoepitheliomas, transitional cell carcinomas of the bladder, as well as holoprosencephaly. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described, but their full length sequences and biological validity cannot be determined currently.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: etID309849.2; FLJ26746; FLJ42602; HGNC:9585; mesenchymal dysplasia; OTTHUMP00000021709; OTTHUMP00000021710; patched; Patched 1; patched homolog 2; patched1; Protein patched homolog 1; PTC; ptc-1; PTCH protein +12b; PTCH protein +4'; PTCH protein -10; PTCH protein -3; PTCH protein -3,4,5; Ptch1 protein +12b; RP11-435O5.3
Gene Aliases: A230106A15Rik; BCNS; HPE7; mes; NBCCS; PTC; PTC1; PTCH; PTCH1; PTCH11; Ptch2
UniProt ID: (Human) Q13635, (Mouse) Q61115
Entrez Gene ID: (Human) 5727, (Rat) 89830, (Mouse) 19206
negative regulation of transcription from RNA polymerase II promoter
branching involved in ureteric bud morphogenesis
in utero embryonic development
cell fate determination
neural tube formation
neural tube closure
heart morphogenesis
signal transduction
smoothened signaling pathway
regulation of mitotic cell cycle
pattern specification process
brain development
negative regulation of cell proliferation
epidermis development
regulation of smoothened signaling pathway
response to mechanical stimulus
organ morphogenesis
dorsal/ventral pattern formation
epidermal cell fate specification
response to chlorate
positive regulation of cholesterol efflux
response to organic cyclic compound
protein processing
spinal cord motor neuron differentiation
neural tube patterning
dorsal/ventral neural tube patterning
neural plate axis specification
embryonic limb morphogenesis
mammary gland development
response to estradiol
response to retinoic acid
regulation of protein localization
limb morphogenesis
hindlimb morphogenesis
regulation of growth
negative regulation of multicellular organism growth
regulation of cell proliferation
response to drug
glucose homeostasis
negative regulation of sequence-specific DNA binding transcription factor activity
keratinocyte proliferation
positive regulation of epidermal cell differentiation
negative regulation of osteoblast differentiation
negative regulation of smoothened signaling pathway
embryonic organ development
negative regulation of epithelial cell proliferation
negative regulation of cell division
pharyngeal system development
mammary gland duct morphogenesis
mammary gland epithelial cell differentiation
smoothened signaling pathway involved in dorsal/ventral neural tube patterning
cell differentiation involved in kidney development
somite development
cellular response to cholesterol
renal system development
cell proliferation involved in metanephros development
protein targeting to plasma membrane
positive regulation of transcription, DNA-templated
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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