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Patched Polyclonal Antibody

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Patched Polyclonal Antibody

Product Details

BS-24459R

Applications
Tested Dilution
Publications

Western Blot (WB)

1:300-1:5,000
-

ELISA (ELISA)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide derived from human Patched (1-100).
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

TBS, pH 7.4, with 50% glycerol, 1% BSA

Contains

0.03% ProClin 300

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

This gene encodes a member of the patched gene family. The encoded protein is the receptor for sonic hedgehog, a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis, as well as the desert hedgehog and indian hedgehog proteins. This gene functions as a tumor suppressor. Mutations of this gene have been associated with basal cell nevus syndrome, esophageal squamous cell carcinoma, trichoepitheliomas, transitional cell carcinomas of the bladder, as well as holoprosencephaly. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described, but their full length sequences and biological validity cannot be determined currently.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: etID309849.2; FLJ26746; FLJ42602; HGNC:9585; mesenchymal dysplasia; OTTHUMP00000021709; OTTHUMP00000021710; patched; Patched 1; patched gene homolog; similar to Drosophila patched protein, Swiss-Prot Accession Number P18502; transmembrane protein; Method: conceptual translation supplied by author; patched homolog 2; patched1; Protein patched homolog 1; PTC; ptc-1; PTCH protein -3; Ptch1 protein +12b; RP11-435O5.3; unnamed protein product

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Gene Aliases: A230106A15Rik; BCNS; BCNS1; mes; NBCCS; PTC; PTC1; PTCH; PTCH1; Ptch2; SLC65B1

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UniProt ID: (Human) Q13635, (Mouse) Q61115

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Entrez Gene ID: (Human) 5727, (Rat) 89830, (Mouse) 19206

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Function(s)
patched binding smoothened binding protein binding hedgehog receptor activity heparin binding cholesterol binding cyclin binding macromolecular complex binding hedgehog family protein binding molecular_function protein complex binding zinc ion binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter branching involved in ureteric bud morphogenesis in utero embryonic development cell fate determination neural tube formation neural tube closure heart morphogenesis signal transduction spermatid development regulation of mitotic cell cycle pattern specification process brain development negative regulation of cell proliferation epidermis development regulation of smoothened signaling pathway response to xenobiotic stimulus response to mechanical stimulus organ morphogenesis dorsal/ventral pattern formation epidermal cell fate specification response to chlorate negative regulation of keratinocyte proliferation positive regulation of cholesterol efflux protein processing spinal cord motor neuron differentiation neural tube patterning dorsal/ventral neural tube patterning neural plate axis specification embryonic limb morphogenesis prostate gland development mammary gland development response to estradiol response to retinoic acid regulation of protein localization limb morphogenesis hindlimb morphogenesis regulation of growth negative regulation of multicellular organism growth regulation of cell proliferation glucose homeostasis response to alkaloid keratinocyte proliferation positive regulation of epidermal cell differentiation negative regulation of osteoblast differentiation negative regulation of smoothened signaling pathway negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated embryonic organ development smooth muscle tissue development epithelial cell proliferation negative regulation of epithelial cell proliferation negative regulation of cell division pharyngeal system development mammary gland duct morphogenesis mammary gland epithelial cell differentiation cell differentiation involved in kidney development somite development cellular response to cholesterol commissural neuron axon guidance stem cell proliferation cell proliferation involved in metanephros development metanephric collecting duct development protein localization to plasma membrane liver regeneration negative regulation of stem cell proliferation smoothened signaling pathway response to organic cyclic compound response to drug negative regulation of sequence-specific DNA binding transcription factor activity smoothened signaling pathway involved in dorsal/ventral neural tube patterning renal system development protein targeting to plasma membrane
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