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Proteintech
Pepsinogen II Polyclonal Antibody
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Product Details
16881-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Pepsinogen II Fusion Protein Ag10332 (1-388 aa encoded by BC073740)
Conjugate
Form
Liquid
Concentration
0.22 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MKWMVVVLV CLQLLEAAVV KVPLKKFKSI RETMKEKGLL GEFLRTHKYD PAWKYRFGDL SVTYEPMAYM DAAYFGEISI GTPPQNFLVL FDTGSSNLWV PSVYCQSQAC TSHSRFNPSE SSTYSTNGQT FSLQYGSGSL TGFFGYDTLT VQSIQVPNQE FGLSENEPGT NFVYAQFDGI MGLAYPALSV DEATTAMQGM VQEGALTSPV FSVYLSNQQG SSGGAVVFGG VDSSLYTGQI YWAPVTQELY WQIGIEEFLI GGQASGWCSE GCQAIVDTGT SLLTVPQQYM SALLQATGAQ EDEYGQFLVN CNSIQNLPSL TFIINGVEFP LPPSSYILSN NGYCTVGVEP TYLSSQNGQP LWILGDVFLR SYYSVYDLGN NRVGFATAA (1-388 aa encoded by BC073740 )
Target Information
This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Gastricsin; pepsin C; Pepsinogen C; pepsinogen group II; preprogastricsin; progastricsin (pepsinogen C); Urinary pepsinogen 1
Gene Aliases: 2210410L06Rik; PEPC; Pg-1; PG1; PGC; PGII; Upg-1; Upg1
UniProt ID: (Human) P20142, (Mouse) Q9D7R7, (Rat) P04073
Entrez Gene ID: (Human) 5225, (Mouse) 109820, (Rat) 24864
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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