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Proteintech
Perforin Polyclonal Antibody
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Product Details
14580-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Chicken
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Perforin Fusion Protein Ag6060 (247-555 aa encoded by BC063043)
Conjugate
Form
Liquid
Concentration
0.28 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: EGLTDNEVE DCLTVEAQVN IGIHGSISAE AKACEEKKKK HKMTASFHQT YRERHSEVVG GHHTSINDLL FGIQAGPEQY SAWVNSLPGS PGLVDYTLEP LHVLLDSQDP RREALRRALS QYLTDRARWR DCSRPCPPGR QKSPRDPCQC VCHGSAVTTQ DCCPRQRGLA QLEVTFIQAW GLWGDWFTAT DAYVKLFFGG QELRTSTVWD NNNPIWSVRL DFGDVLLATG GPLRLQVWDQ DSGRDDDLLG TCDQAPKSGS HEVRCNLNHG HLKFRYHARC LPHLGGGTCL DYVPQMLLGE PPGNRSGAVW (247-555 aa encoded by BC063043)
Target Information
Perforin is one of the major cytolytic proteins of cytolytic granules. Perforin is a cytolytic mediator and is stored in and released by cytoplasmic granules. Moreover, perforin is involved in immune defense against tumors and virus infections as mediated by cytotoxic lymphocytes. Perforin is a 555 amino acid protein with a 21 amino acid signal peptide, and has a molecular weight of 70 to 75 kD. Perforin is a pore forming protein with a mechanism of transmembrane channel formation similar to C9, and homology between perforin and C9 have been demonstrated. Studies show that perforin is expressed only in killer cell lines and not in helper T lymphocytes or other tumor cells tested. Perforin is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in the perforin gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. Alternative splicing results in multiple transcript variants of perforin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Cytolysin; lymphocyte pore forming protein; Lymphocyte pore-forming protein; OMAK; OTTHUMP00000019759; P1; perforin 1 (pore forming protein); Perforin-1; Perforin1; PFP; PGFL; PIGF; PIGF-2; PLGF; pore forming protein; PRF1 (pore forming protein 1); RP11-710A11.3
Gene Aliases: FLH2; HPLH2; P1; Pfn; PFN1; PFP; Prf-1; PRF1
UniProt ID: (Human) P14222, (Mouse) P10820
Entrez Gene ID: (Human) 5551, (Mouse) 18646
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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