This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated. View Details
Recommended positive controls: HeLa, A431, H1299, HeLaS3, NIH-3T3.
Predicted reactivity: Pig (95%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Periostin (PN), also designated osteoblast-specific factor 2 (OSF-2), is a disulfide linked protein originally isolated as a osteoblast-specific factor. Periostin is a secreted protein that binds heparin and functions as a ligand for alpha(V)beta(3) and alpha(V)beta(5) integrins. In preosteoblasts, Periostin acts as a cell adhesion molecule and plays a role in osteoblast recruitment, spreading and attachment. Periostin is mainly detected in lower gastrointestinal tract, aorta, stomach, placenta, uterus and breast tissues but is up-regulated in epithelial ovarian tumors and overexpressed in breast cancer. Expression of Periostin is increased by bone morphogenetic protein (BMP2) and transforming growth factor beta 1(TGF beta 1). Periostin contains a typical signal sequence, followed by a cysteine-rich domain, a fourfold repeated domain, which shows homology with the insect protein fasciclin, and a C-terminal domain.
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For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: fasciclin I-like; OSF-2; OSF2; osteoblast specific factor 2; osteoblast specific factor 2 (fasciclin I-like); Osteoblast-specific factor 2; PDLPOSTN; periodontal ligament-specific periostin; Periostin; periostin isoform thy2; periostin isoform thy4; periostin isoform thy6; periostin isoform thy8; periostin, osteoblast specific factor; periostin-like factor; PN; RP11-412K4.1
Gene Aliases: A630052E07Rik; AI747096; OSF-2; OSF2; PDLPOSTN; peri; PLF; PN; POSTN