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Invitrogen
Phospho-ATR (Ser428) Polyclonal Antibody
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FIGURE: 1 / 6
Phospho-ATR (Ser428) Antibody (720107) in ICC/IF
For immunofluorescence analysis HeLa cells were fixed and permeabilized for detection of ATR (pS428) using ATR (pS428) Rabbit Polyclonal antibody (Product # 720107, 2 µg/mL) and labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A27034, 1:2000). Nuclei (blue) were stained using SlowFade® Gold Antifade Mountant with DAPI (Product # S36938), ... View More
Product Details
720107
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide corresponding to Human ATR (aa 424-432)
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2, with 0.1% BSA, 30% glycerol
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
These Polyclonal antibodies are of rabbit origin developed by immunizing animals with proteins or peptides. The polyclonal antibody is purified by affinity purification from the rabbit sera generated after immunizing the rabbits with a specific type of protein or peptide. The purified antibody is tested for its functionality in various relevant research applications. The antibody is developed for Research Use Only and is non-hazardous or non-infectious in nature.
This antibody is predicted to react with Monkey, Cat, Sheep and Bovine.
Target Information
The protein encoded by this gene is a serine/threonine kinase and DNA damage sensor, activating cell cycle checkpoint signaling upon DNA stress. The encoded protein can phosphorylate and activate several proteins involved in the inhibition of DNA replication and mitosis, and can promote DNA repair, recombination, and apoptosis. This protein is also important for fragile site stability and centrosome duplication. Defects in this gene are a cause of Seckel syndrome 1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 2310008J16Rik; 2810405N18Rik; Ataxia telangiectasia and Rad3-related protein; atr; ATR serine/threonine kinase; EC 2.7.11.1; FRAP-related protein 1; FRAP-related protein-1; kinase ATR; MEC1, mitosis entry checkpoint 1, homolog; protein kinase ATR; Serine/threonine-protein kinase ATR; TEM8
Gene Aliases: ATR; FCTCS; FRP1; MEC1; SCKL; SCKL1
UniProt ID: (Human) Q13535
Entrez Gene ID: (Human) 545
DNA damage checkpoint
G2/M transition of mitotic cell cycle
telomere maintenance
nucleobase-containing compound metabolic process
DNA replication
DNA repair
double-strand break repair
chromatin remodeling
cellular response to DNA damage stimulus
nuclear envelope organization
negative regulation of DNA replication
response to xenobiotic stimulus
response to mechanical stimulus
replication fork processing
positive regulation of telomere maintenance via telomerase
cellular response to UV
interstrand cross-link repair
positive regulation of DNA damage response, signal transduction by p53 class mediator
mitotic G2/M transition checkpoint
response to arsenic-containing substance
nuclear envelope disassembly
protein localization to chromosome, telomeric region
cellular response to gamma radiation
regulation of cellular response to stress
replicative senescence
establishment of RNA localization to telomere
establishment of macromolecular complex localization to telomere
DNA strand resection involved in replication fork processing
regulation of cellular response to heat
positive regulation of telomerase catalytic core complex assembly
protein localization to site of double-strand break
regulation of double-strand break repair
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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