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Phospho-IKKi (Ser172) Polyclonal Antibody
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Product Details
BS-8583R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synstic phosphopeptide derived from human IKKi/IKKE around the phosphorylation site of Ser172 [FV (p-S)VY].
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
IKBKE is an activator of nuclear factor-kappa-B. Over expression of IKBKE has been observed in breast cancer cells, and suppression of IKBKE induces cell death. NF-kappa-B is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-kappa-B mediates the expression of a great variety of genes in response to extracellular stimuli. NF-kappa-B is associated with Ikappa-B proteins in the cell cytoplasm, which inhibit NF-kappa-B activity. Ikappa-B is phosphorylated by Ikappa-B kinase (IKK) complex that contains IKK-a, IKK-b, and IKK-gamma. A novel molecule in the IKK complex was recently identified and designated IKK-iota/IKK-i. IKK epsilon is required for the activation of NF-kappa-B by PMA and T cell receptors but not by TNF-a and IL-1. IKK-iota/IKK-i message is expressed in a variety of tissues and is inducible by TNF-a, IL-1, and LPS.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: I-kappa-B kinase epsilon; IKK-E; IKK-epsilon; IKK-i; IKK-related kinase epsilon; IKKe; IKK-related kinase; Inducible I kappa-B kinase; inducible IKappaB kinase; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon; inhibitor of kappaB kinase epsilon; Inhibitor of nuclear factor kappa-B kinase subunit epsilon; KIAA0151; RP11-534L20.1
Gene Aliases: AW558201; IKBKE; IKK-E; IKK-i; IKKE; IKKepsilon; IKKI; KIAA0151
UniProt ID: (Human) Q14164, (Mouse) Q9R0T8
Entrez Gene ID: (Human) 9641, (Rat) 363984, (Mouse) 56489
nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
protein binding
ATP binding
IkappaB kinase activity
kinase activity
transferase activity
protein phosphatase binding
ubiquitin protein ligase binding
K48-linked polyubiquitin binding
identical protein binding
K63-linked polyubiquitin binding
NF-kappaB-inducing kinase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
protein modifying enzyme
activation of innate immune response
response to stress
immune response
cellular response to DNA damage stimulus
intrinsic apoptotic signaling pathway in response to DNA damage
gene expression
positive regulation of lipid storage
positive regulation of type I interferon production
response to cytokine
response to type I interferon
response to interferon-beta
intracellular signal transduction
positive regulation of I-kappaB kinase/NF-kappaB signaling
regulation of protein complex assembly
mRNA stabilization
defense response to virus
type I interferon signaling pathway
positive regulation of type I interferon-mediated signaling pathway
interleukin-17-mediated signaling pathway
cellular response to virus
protein phosphorylation
I-kappaB phosphorylation
NIK/NF-kappaB signaling
phosphorylation
signal transduction by protein phosphorylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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