Invitrogen

Phospho-RAC1 (Ser71) Polyclonal Antibody

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Datasheet
Protocols
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Datasheet
Protocols
Questions & Answers
Tech Support
Phospho-RAC1 (Ser71) Polyclonal Antibody

Product Details

PA5-104640

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human RAC1(Accession P63000), corresponding to amino acid residues around phosphorylated Ser71.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

sequential chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2816115

Product Specific Information

Antibody detects endogenous levels of Rac1/cdc42 only when phosphorylated at Ser71.

Target Information

The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Two transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: Cell migration-inducing gene 5 protein; MGC111543; p21-Rac1; Ras-like protein TC25; Ras-related C3 botulinum toxin substrate 1; ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein Rac1); rho family, small GTP binding protein Rac1

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Gene Aliases: AL023026; D5Ertd559e; MIG5; p21-Rac1; Rac; Rac-1; RAC1; TC-25; TC25

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UniProt ID: (Human) P63000, (Mouse) P63001, (Rat) Q6RUV5

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Entrez Gene ID: (Human) 5879, (Mouse) 19353, (Rat) 363875

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Function(s)
GTPase activity protein binding GTP binding Rab GTPase binding enzyme binding protein kinase binding GTP-dependent protein binding thioesterase binding histone deacetylase binding Rho GDP-dissociation inhibitor binding nucleotide binding immunoglobulin small GTPase
Process(es)
positive regulation of protein phosphorylation auditory receptor cell morphogenesis mast cell chemotaxis epithelial cell morphogenesis movement of cell or subcellular component inflammatory response hyperosmotic response cell adhesion cell-matrix adhesion G-protein coupled receptor signaling pathway small GTPase mediated signal transduction axon guidance blood coagulation cell proliferation regulation of cell size response to wounding anatomical structure morphogenesis regulation of hydrogen peroxide metabolic process positive regulation of lamellipodium assembly regulation of fibroblast migration positive regulation of cell-substrate adhesion regulation of neuron maturation cerebral cortex radially oriented cell migration embryonic olfactory bulb interneuron precursor migration cerebral cortex GABAergic interneuron development lamellipodium assembly actin cytoskeleton organization actin filament polymerization platelet activation regulation of cell migration positive regulation of actin filament polymerization T cell costimulation ruffle organization negative regulation of interleukin-23 production substrate adhesion-dependent cell spreading positive regulation of Rho protein signal transduction intracellular signal transduction Fc-epsilon receptor signaling pathway Fc-gamma receptor signaling pathway involved in phagocytosis positive regulation of apoptotic process positive regulation of phosphatidylinositol 3-kinase activity engulfment of apoptotic cell cell-cell junction organization bone resorption positive regulation of DNA replication vascular endothelial growth factor receptor signaling pathway ephrin receptor signaling pathway negative regulation of receptor-mediated endocytosis anatomical structure arrangement dendrite morphogenesis cell motility homeostasis of number of cells within a tissue regulation of defense response to virus by virus regulation of small GTPase mediated signal transduction positive regulation of stress fiber assembly localization within membrane positive regulation of focal adhesion assembly synaptic transmission, GABAergic Wnt signaling pathway, planar cell polarity pathway regulation of respiratory burst cellular response to mechanical stimulus semaphorin-plexin signaling pathway dopaminergic neuron differentiation protein localization to plasma membrane positive regulation of neutrophil chemotaxis cochlea morphogenesis ruffle assembly positive regulation of substrate adhesion-dependent cell spreading endocytosis phagocytosis, engulfment chemotaxis cytoskeleton organization actin filament organization metabolic process dendrite development cell migration regulation of cell morphogenesis Rac protein signal transduction
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