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Invitrogen
Phospho-RAD51 (Thr309) Polyclonal Antibody
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FIGURE: 1 / 1
Phospho-RAD51 (Thr309) Antibody (PA5-106033) in WB
Western blot analysis of Phospho-RAD51 (Thr309) in serum treated COS7 whole cell lysate (absence (-) or presence (+) of non-phospho and phospho peptide). Samples were incubated with Phospho-RAD51 (Thr309) polyclonal antibody (Product # PA5-106033).
Product Details
PA5-106033
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Non-human primate
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human RAD51(Accession Q06609), corresponding to amino acid residues around phosphorylated Thr309.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
sequential chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of RAD51 only when phosphorylated at Thr309.
Target Information
RAD51 plays a critical role in homologous strand exchange, a key step in DNA repair through homologous recobination. It binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. RAD51 catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. It binds to a single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Mutations in the gene can results in breast cancer, mirror movements 2 and fanconi anemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BRCA1/BRCA2-containing complex, subunit 5; DNA repair protein RAD51 homolog 1; HsRAD51; RAD51; RAD51 homolog A; RecA, E. coli, homolog of; RecA-like protein; recombination protein A; unnamed protein product
Gene Aliases: AV304093; BRCC5; FANCR; HRAD51; HsRad51; HsT16930; MRMV2; RAD51; RAD51A; RECA
UniProt ID: (Human) Q06609, (Mouse) Q08297
Entrez Gene ID: (Human) 5888, (Mouse) 19361
recombinase activity
nucleotide binding
DNA binding
chromatin binding
double-stranded DNA binding
single-stranded DNA binding
protein binding
ATP binding
DNA-dependent ATPase activity
single-stranded DNA-dependent ATP-dependent DNA helicase activity
enzyme binding
identical protein binding
DNA polymerase binding
ATP-dependent DNA damage sensor activity
damaged DNA binding
protein C-terminus binding
single-stranded DNA-dependent ATPase activity
DNA metabolism protein
telomere maintenance via recombination
double-strand break repair via homologous recombination
DNA recombinase assembly
DNA metabolic process
DNA repair
DNA recombination
mitotic recombination
cellular response to DNA damage stimulus
meiosis I
reciprocal meiotic recombination
response to xenobiotic stimulus
response to toxic substance
response to X-ray
regulation of double-strand break repair via homologous recombination
telomere maintenance via telomere lengthening
replication fork processing
telomere organization
interstrand cross-link repair
strand invasion
meiotic cell cycle
chromosome organization involved in meiotic cell cycle
cellular response to alkaloid
cellular response to ionizing radiation
cellular response to gamma radiation
cellular response to hydroxyurea
cellular response to cisplatin
cellular response to camptothecin
response to glucoside
replication-born double-strand break repair via sister chromatid exchange
mitotic recombination-dependent replication fork processing
double-strand break repair involved in meiotic recombination
regulation of DNA damage checkpoint
regulation of protein phosphorylation
DNA unwinding involved in DNA replication
meiotic nuclear division
positive regulation of DNA ligation
protein homooligomerization
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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