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Antibody detects endogenous levels of Retinoic Acid Receptor alpha/beta only when phosphorylated at Retinoic AcSer96.
Retinoic acid, a metabolite of vitamin A, is necessary for normal organogenesis but acts as a teratogen at high levels during embryonic and fetal development. Retinoic acid functions through its interaction with the nuclear protein, retinoic acid receptor (RAR). RAR belongs to the steroid and thyroid hormone superfamily of nuclear receptor proteins which exert their effects by binding to specific DNA response elements, thus regulating gene expression in target cells. RAR exists as three major subtypes: alpha, beta and gamma.
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Protein Aliases: HBV-activated protein; hepatitis B virus activated protein; Nuclear receptor subfamily 1 group B member 1; Nuclear receptor subfamily 1 group B member 2; nucleophosmin-retinoic acid receptor alpha fusion protein NPM-RAR long form; RAR alpha 1; RAR-alpha; RAR-beta; RAR-epsilon; retinoic acid; retinoic acid nuclear receptor alpha variant 1; retinoic acid nuclear receptor alpha variant 2; retinoic acid receptor; Retinoic acid receptor alpha; Retinoic acid receptor beta; retinoic acid receptor, alpha polypeptide; retinoic acid receptor, beta polypeptide
Gene Aliases: A830025K23; HAP; MCOPS12; NR1B1; NR1B2; RAR; RARA; RARalpha1; RARB; RARbeta1; RRB2
UniProt ID: (Human) P10276, (Human) P10826, (Mouse) P11416, (Mouse) P22605
Entrez Gene ID: (Human) 5914, (Human) 5915, (Rat) 24705, (Mouse) 19401, (Rat) 24706, (Mouse) 218772
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