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Invitrogen
Phospho-RARA/RARB (Ser96) Polyclonal Antibody
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Product Details
PA5-64622
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human Retinoic Acid Receptor alpha/beta (Phospho-Ser96)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Phospho-RARA/RARB (Ser96) Polyclonal Antibody detects endogenous levels of RARA/RARB only when phosphorylated at Ser96.
Target Information
Retinoic acid, a metabolite of vitamin A, is necessary for normal organogenesis but acts as a teratogen at high levels during embryonic and fetal development. Retinoic acid functions through its interaction with the nuclear protein, retinoic acid receptor (RAR). RAR belongs to the steroid and thyroid hormone superfamily of nuclear receptor proteins which exert their effects by binding to specific DNA response elements, thus regulating gene expression in target cells. RAR exists as three major subtypes: alpha, beta and gamma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: HBV-activated protein; hepatitis B virus activated protein; Nuclear receptor subfamily 1 group B member 1; Nuclear receptor subfamily 1 group B member 2; nucleophosmin-retinoic acid receptor alpha fusion protein NPM-RAR long form; RAR alpha 1; RAR-alpha; RAR-beta; RAR-epsilon; retinoic acid; retinoic acid nuclear receptor alpha variant 1; retinoic acid nuclear receptor alpha variant 2; retinoic acid receptor; Retinoic acid receptor alpha; Retinoic acid receptor beta; retinoic acid receptor, alpha polypeptide; retinoic acid receptor, beta polypeptide
Gene Aliases: A830025K23; HAP; MCOPS12; NR1B1; NR1B2; RAR; RARA; RARalpha1; RARB; RARbeta1; RRB2
UniProt ID: (Human) P10276, (Human) P10826, (Mouse) P11416, (Mouse) P22605
Entrez Gene ID: (Human) 5914, (Human) 5915, (Rat) 24705, (Mouse) 19401, (Rat) 24706, (Mouse) 218772
translation repressor activity, nucleic acid binding
RNA polymerase II regulatory region sequence-specific DNA binding
retinoic acid binding
transcription factor activity, sequence-specific DNA binding
steroid hormone receptor activity
retinoic acid receptor activity
transcription coactivator activity
transcription corepressor activity
receptor binding
protein binding
transcription factor binding
drug binding
zinc ion binding
enzyme binding
protein domain specific binding
chromatin DNA binding
histone deacetylase binding
protein kinase B binding
retinoic acid-responsive element binding
protein heterodimerization activity
mRNA 5'-UTR binding
protein kinase A binding
alpha-actinin binding
DNA binding
protein complex binding
retinoid X receptor binding
RNA polymerase II regulatory region DNA binding
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
phosphatidylinositol 3-kinase regulator activity
sequence-specific DNA binding
transcription regulatory region DNA binding
regulatory region DNA binding
metal ion binding
C4 zinc finger nuclear receptor
negative regulation of transcription from RNA polymerase II promoter
ureteric bud development
neural tube closure
liver development
glandular epithelial cell development
outflow tract septum morphogenesis
growth plate cartilage development
transcription initiation from RNA polymerase II promoter
protein phosphorylation
signal transduction
germ cell development
spermatogenesis
female pregnancy
positive regulation of cell proliferation
negative regulation of cell proliferation
hippocampus development
prostate gland development
negative regulation of granulocyte differentiation
embryonic camera-type eye development
regulation of myelination
response to estradiol
response to retinoic acid
negative regulation of interferon-gamma production
negative regulation of tumor necrosis factor production
positive regulation of interleukin-13 production
positive regulation of interleukin-4 production
positive regulation of interleukin-5 production
response to vitamin A
response to cytokine
multicellular organism growth
negative regulation of apoptotic process
apoptotic cell clearance
steroid hormone mediated signaling pathway
response to ethanol
positive regulation of T-helper 2 cell differentiation
positive regulation of neuron differentiation
positive regulation of cell cycle
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
negative regulation of translational initiation
regulation of synaptic plasticity
retinoic acid receptor signaling pathway
positive regulation of binding
ventricular cardiac muscle cell differentiation
Sertoli cell fate commitment
limb development
face development
trachea cartilage development
chondroblast differentiation
negative regulation of cartilage development
cellular response to lipopolysaccharide
cellular response to retinoic acid
cellular response to estrogen stimulus
retinal pigment epithelium development
striatum development
negative regulation of chondrocyte differentiation
embryonic hindlimb morphogenesis
positive regulation of apoptotic process
embryonic eye morphogenesis
embryonic digestive tract development
transcription, DNA-templated
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
male gonad development
positive regulation of gene expression
negative regulation of gene expression
positive regulation of phosphatidylinositol 3-kinase signaling
negative regulation of translation
intracellular estrogen receptor signaling pathway
regulation of granulocyte differentiation
regulation of apoptotic process
regulation of phosphatidylinositol 3-kinase activity
negative regulation of cell differentiation
positive regulation of protein kinase B signaling
bone development
positive regulation of ERK1 and ERK2 cascade
neurogenesis
positive regulation of programmed cell death
retina development in camera-type eye
regulation of transcription from RNA polymerase II promoter
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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