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Invitrogen

Phospho-RARA/RARB (Ser96) Polyclonal Antibody

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Phospho-RARA/RARB (Ser96) Polyclonal Antibody

Product Details

PA5-64622

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human Retinoic Acid Receptor alpha/beta (Phospho-Ser96)
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2662518

Product Specific Information

Phospho-RARA/RARB (Ser96) Polyclonal Antibody detects endogenous levels of RARA/RARB only when phosphorylated at Ser96.

Target Information

Retinoic acid, a metabolite of vitamin A, is necessary for normal organogenesis but acts as a teratogen at high levels during embryonic and fetal development. Retinoic acid functions through its interaction with the nuclear protein, retinoic acid receptor (RAR). RAR belongs to the steroid and thyroid hormone superfamily of nuclear receptor proteins which exert their effects by binding to specific DNA response elements, thus regulating gene expression in target cells. RAR exists as three major subtypes: alpha, beta and gamma.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: HBV-activated protein; hepatitis B virus activated protein; nuclear receptor; Nuclear receptor subfamily 1 group B member 1; Nuclear receptor subfamily 1 group B member 2; nuclear receptor; RAR beta; nucleophosmin-retinoic acid receptor alpha fusion protein NPM-RAR long form; open reading frame 1; putative; PML gene product; PML-DDX5-RARA fusion; PML-DDX5-RARA fusion protein; RAR alpha 1; RAR beta 1'; RAR-alpha; RAR-beta; RAR-epsilon; RARA; RARB; RARbeta isoform 5; retinoic acid; retinoic acid receptor; Retinoic acid receptor alpha; Retinoic acid receptor beta; retinoic acid receptor, alpha polypeptide; retinoic acid receptor, beta polypeptide; TTMV/RARA fusion; TTMV/RARA fusion protein; unnamed protein product

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Gene Aliases: A830025K23; HAP; MCOPS12; NR1B1; NR1B2; RAR; RARA; RARalpha; RARalpha1; RARB; RARbeta; RARbeta1; RRB2

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UniProt ID: (Human) P10276, (Human) P10826, (Mouse) P11416, (Mouse) P22605

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Entrez Gene ID: (Human) 5914, (Human) 5915, (Rat) 24705, (Mouse) 19401, (Rat) 24706, (Mouse) 218772

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Function(s)
translation repressor activity, nucleic acid binding transcription regulatory region sequence-specific DNA binding RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding transcription coactivator binding retinoic acid binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding receptor binding protein binding zinc ion binding enzyme binding protein domain specific binding chromatin DNA binding histone deacetylase binding protein kinase B binding sequence-specific DNA binding retinoic acid-responsive element binding metal ion binding mRNA 5'-UTR binding protein kinase A binding alpha-actinin binding heterocyclic compound binding sequence-specific double-stranded DNA binding macromolecular complex binding retinoid X receptor binding RNA polymerase II regulatory region DNA binding steroid hormone receptor activity retinoic acid receptor activity transcription coactivator activity transcription corepressor activity transcription factor binding drug binding phosphatidylinositol 3-kinase regulator activity transcription regulatory region DNA binding protein heterodimerization activity regulatory region DNA binding protein complex binding C4 zinc finger nuclear receptor
Process(es)
negative regulation of transcription from RNA polymerase II promoter ureteric bud development neural tube closure liver development glandular epithelial cell development outflow tract septum morphogenesis growth plate cartilage development regulation of transcription, DNA-templated protein phosphorylation germ cell development spermatogenesis female pregnancy positive regulation of cell proliferation negative regulation of cell proliferation male gonad development positive regulation of gene expression negative regulation of gene expression negative regulation of translation hippocampus development cell differentiation prostate gland development regulation of granulocyte differentiation negative regulation of granulocyte differentiation embryonic camera-type eye development regulation of myelination response to estradiol response to retinoic acid negative regulation of interferon-gamma production negative regulation of tumor necrosis factor production positive regulation of interleukin-13 production positive regulation of interleukin-4 production positive regulation of interleukin-5 production response to vitamin A response to cytokine multicellular organism growth mRNA transcription from RNA polymerase II promoter regulation of apoptotic process negative regulation of apoptotic process apoptotic cell clearance response to ethanol negative regulation of cell differentiation positive regulation of T-helper 2 cell differentiation positive regulation of neuron differentiation positive regulation of cell cycle negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter regulation of synaptic plasticity retinoic acid receptor signaling pathway positive regulation of binding ventricular cardiac muscle cell differentiation Sertoli cell fate commitment limb development face development bone development trachea cartilage development chondroblast differentiation negative regulation of cartilage development cellular response to lipopolysaccharide cellular response to retinoic acid cellular response to estrogen stimulus nucleus-associated proteasomal ubiquitin-dependent protein catabolic process regulation of hematopoietic progenitor cell differentiation negative regulation of pri-miRNA transcription from RNA polymerase II promoter apoptotic process signal transduction cell proliferation programmed cell death striatum development neurogenesis negative regulation of chondrocyte differentiation embryonic hindlimb morphogenesis positive regulation of apoptotic process positive regulation of programmed cell death embryonic eye morphogenesis embryonic digestive tract development neural precursor cell proliferation stem cell proliferation negative regulation of stem cell proliferation transcription, DNA-templated transcription from RNA polymerase II promoter positive regulation of phosphatidylinositol 3-kinase signaling intracellular estrogen receptor signaling pathway steroid hormone mediated signaling pathway regulation of phosphatidylinositol 3-kinase activity negative regulation of translational initiation positive regulation of protein kinase B signaling positive regulation of ERK1 and ERK2 cascade retinal pigment epithelium development retina development in camera-type eye regulation of transcription from RNA polymerase II promoter
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