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Invitrogen
Phospho-ROS1 (Tyr2114) Polyclonal Antibody
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FIGURE: 1 / 2
Phospho-ROS1 (Tyr2114) Antibody (PA5-37350) in WB
Western blot analysis of Phospho-ROS1 (Tyr2114) in Lane 1: C6 whole cell lysate (40 µg), Lane 2: HeLa whole cell lysate (40 µg), Lane 3: the Brain tissue lysate of mouse (40 µg), Lane 4: the Brain tissue lysate of rat (40 µg), Lane 5: HEK293T whole cell lysate (40 µg), Lane 6: A549 whole cell lysate (40 µg). Samples were incubated with Phospho-ROS1 (Tyr2114) polyclonal antibody (Product # PA5-37350) at a di... View More
Product Details
PA5-37350
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic phosphopeptide derived from human ROS around the phosphorylation site of Tyrosine 2114
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody detects endogenous protein at a molecular weight of 264 kDa.
Purity is >95% by SDS-PAGE.
Target Information
ROS1 is a tyrosine kinase that functions as a growth or differentiation factor receptor. Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The tyrosine kinase (TK) group is mainly involved in the regulation of cell-cell interactions such as differentiation, adhesion, motility and death. There are currently about 90 TK genes sequenced, 58 are of receptor protein TK (e.g. EGFR, EPH, FGFR, PDGFR, TRK, and VEGFR families), and 32 of cytosolic TK (e.g. ABL, FAK, JAK, and SRC families).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: c-ros oncogene 1 , receptor tyrosine kinase; c-Ros receptor tyrosine kinase; c-ros-1; heart - derived c - ros - 1 proto - oncogene; Proto-oncogene c-Ros; Proto-oncogene c-Ros-1; Proto-oncogene tyrosine-protein kinase ROS; Receptor tyrosine kinase c-ros oncogene 1; ROS proto-oncogene 1 , receptor tyrosine kinase; Ros1 proto-oncogene; RP1-179P9.1; transmembrane protein kinase 3); transmembrane tyrosine-specific protein kinase; transmembrane tyrosine-specific protein kinase precursor; v-ros avian UR2 sarcoma virus oncogene homolog 1; v-ros UR2 sarcoma virus oncogene homolog 1
Gene Aliases: c-ros; c-ros-1; MCF3; ROS; Ros-1; ROS1; ROS1C
UniProt ID: (Human) P08922, (Rat) Q63132, (Mouse) Q78DX7
Entrez Gene ID: (Human) 6098, (Rat) 25346, (Mouse) 19886
nucleotide binding
protein kinase activity
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
protein binding
ATP binding
kinase activity
transferase activity
protein phosphatase binding
transferase activity, transferring phosphorus-containing groups
transmembrane signal receptor
regulation of cell growth
columnar/cuboidal epithelial cell development
protein phosphorylation
transmembrane receptor protein tyrosine kinase signaling pathway
spermatogenesis
cell differentiation
regulation of TOR signaling
regulation of ERK1 and ERK2 cascade
regulation of intracellular signal transduction
cell proliferation
negative regulation of gene expression
regulation of phosphate transport
cell growth
peptidyl-tyrosine phosphorylation
signal transduction by protein phosphorylation
peptidyl-tyrosine autophosphorylation
phosphorylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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