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Invitrogen
Phospho-RPS6 (Ser235, Ser236) Polyclonal Antibody
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FIGURE: 1 / 3
Phospho-RPS6 (Ser235, Ser236) Antibody (PA5-117323) in WB
Western blot analysis of Phospho-RPS6 (Ser235, Ser236) in Untreated (–) and treated (+) HeLa whole cell extracts (30 µg). Samples were separated with 12% SDS-PAGE and incubated in Phospho-RPS6 (Ser235, Ser236) polyclonal antibody (Product # PA5-117323) using a dilution of 1:1,000.
Product Details
PA5-117323
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Carrier-protein conjugated synthetic peptide surrounding phospho Ser235/Ser236 of human RPS6. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1.4 mg/mL
Amount
140 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol, 1% BSA
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Centrifuge briefly prior to opening.
Target Information
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 40S subunit. The protein belongs to the S6E family of ribosomal proteins. It is the major substrate of protein kinases in the ribosome, with subsets of five C-terminal serine residues phosphorylated by different protein kinases. Phosphorylation is induced by a wide range of stimuli, including growth factors, tumor-promoting agents, and mitogens. Dephosphorylation occurs at growth arrest. The protein may contribute to the control of cell growth and proliferation through the selective translation of particular classes of mRNA. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 40S ribosomal protein S6; OTTHUMP00000021121; OTTHUMP00000021122; Phosphoprotein NP33; ribosomal protein S6; RP11-513M16.6; RS6; Small ribosomal subunit protein eS6; unnamed protein product
Gene Aliases: eS6; OK/SW-cl.2; RPS6; S6; S6R
UniProt ID: (Human) P62753, (Mouse) P62754
Entrez Gene ID: (Human) 6194, (Mouse) 20104
ribosomal small subunit assembly
cytoplasmic translation
rRNA processing
translation
positive regulation of cell proliferation
TOR signaling
response to insulin
ribosomal small subunit biogenesis
glucose homeostasis
positive regulation of apoptotic process
cellular response to ethanol
negative regulation of bicellular tight junction assembly
G1/S transition of mitotic cell cycle
placenta development
T cell proliferation involved in immune response
activation-induced cell death of T cells
mitotic nuclear division
mitotic cell cycle checkpoint
gastrulation
oogenesis stage
T cell differentiation in thymus
negative regulation of apoptotic process
erythrocyte development
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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