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Invitrogen

Phospho-RUNX1 (Ser249) Polyclonal Antibody

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Phospho-RUNX1 (Ser249) Polyclonal Antibody

Product Details

PA5-104570

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Non-human primate, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human RUNX1(Accession Q01196), corresponding to amino acid residues around phosphorylated Ser249.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

sequential chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2816045

Product Specific Information

Antibody detects endogenous levels of RUNX1 / AML1 only when phosphorylated at Ser249.

Target Information

RUNX1 belongs to the mammalian RUNX family of DNA binding proteins that regulate the expression of genes involved in cellular differentiation and cell cycle progression. RUNX1 is essential for hematopoietic stem cell generation in the vascular regions of the aorta, vitelline and umbilical arteries, yolk sac and placenta. RUNX1 is expressed in all tissues except brain and heart, with highest levels in thymus, bone marrow and peripheral blood.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Acute myeloid leukemia 1 protein; AML-1; aml1; aml1 oncogene; AML1-ETO fusion; AML1-ETO fusion protein; AML1-EVI-1 fusion protein; CBF-alpha 2; CBF-alpha-2; core binding factor alpha 2; core-binding factor runt domain alpha subunit 2 (acute myeloid leukemia 1 oncogene); Core-binding factor subunit alpha-2; core-binding factor, runt domain, alpha subunit 2; mutant RUNX1; Oncogene AML-1; OTTHUMP00000108697; OTTHUMP00000108700; OTTHUMP00000108702; PEA2-alpha B; PEBP2-alpha B; Polyomavirus enhancer-binding protein 2 alpha B subunit; RUN1; runt domain, alpha subunit 2; runt related transcription factor 1; Runt-related transcription factor 1; RUNX1 with skipped exon 5; SL3-3 enhancer factor 1 alpha B subunit; SL3/AKV core-binding factor alpha B subunit

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Gene Aliases: AML1; AML1-EVI-1; AMLCR1; CBF-alpha-2; CBF2alpha; CBFA2; EVI-1; Pebp2a2; PEBP2aB; PEBP2alpha; Pebpa2b; RUNX1

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UniProt ID: (Human) Q01196, (Rat) Q63046

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Entrez Gene ID: (Human) 861, (Rat) 50662, (Mouse) 12394

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Function(s)
transcription regulatory region sequence-specific DNA binding RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcription corepressor binding transcription coactivator binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding calcium ion binding protein binding ATP binding protein homodimerization activity protein heterodimerization activity DNA-binding transcription factor binding sequence-specific double-stranded DNA binding regulatory region DNA binding core promoter binding molecular_function transcription factor binding repressing transcription factor binding Runt transcription factor
Process(es)
negative regulation of transcription from RNA polymerase II promoter ossification chondrocyte differentiation myeloid leukocyte differentiation regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter regulation of plasminogen activation hemopoiesis myeloid cell differentiation neuron differentiation negative regulation of granulocyte differentiation positive regulation of granulocyte differentiation positive regulation of interleukin-2 production positive regulation of collagen biosynthetic process negative regulation of CD4-positive, alpha-beta T cell differentiation positive regulation of CD8-positive, alpha-beta T cell differentiation regulation of cell differentiation positive regulation of angiogenesis positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter peripheral nervous system neuron development positive regulation of developmental process positive regulation of multicellular organismal process regulation of cardiac muscle cell proliferation cardiac muscle tissue regeneration hematopoietic stem cell proliferation positive regulation of extracellular matrix organization regulation of connective tissue replacement regulation of multicellular organismal development skeletal system development in utero embryonic development liver development myeloid progenitor cell differentiation transcription, DNA-templated central nervous system development negative regulation of cell proliferation regulation of signal transduction hair follicle morphogenesis response to retinoic acid embryonic hemopoiesis behavioral response to pain neuron development definitive hemopoiesis regulation of hair follicle cell proliferation cellular response to transforming growth factor beta stimulus positive regulation of cell maturation positive regulation of progesterone secretion regulation of T cell anergy transcription from RNA polymerase II promoter positive regulation of interferon-gamma production negative regulation of transcription, DNA-templated
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