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Invitrogen
Phospho-RUNX1 (Ser276) Polyclonal Antibody
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Product Details
PA5-104950
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human RUNX1(Accession Q01196), corresponding to amino acid residues around phosphorylated Ser276.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
sequential chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of RUNX1 / AML1 only when phosphorylated at Serine 276.
Target Information
RUNX1 belongs to the mammalian RUNX family of DNA binding proteins that regulate the expression of genes involved in cellular differentiation and cell cycle progression. RUNX1 is essential for hematopoietic stem cell generation in the vascular regions of the aorta, vitelline and umbilical arteries, yolk sac and placenta. RUNX1 is expressed in all tissues except brain and heart, with highest levels in thymus, bone marrow and peripheral blood.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Acute myeloid leukemia 1 protein; AML-1; aml1 oncogene; AML1-EVI-1 fusion protein; CBF-alpha 2; CBF-alpha-2; core binding factor alpha 2; core-binding factor runt domain alpha subunit 2 (acute myeloid leukemia 1 oncogene); Core-binding factor subunit alpha-2; core-binding factor, runt domain, alpha subunit 2; Oncogene AML-1; OTTHUMP00000108697; OTTHUMP00000108700; OTTHUMP00000108702; PEA2-alpha B; PEBP2-alpha B; Polyomavirus enhancer-binding protein 2 alpha B subunit; RUN1; runt domain, alpha subunit 2; runt related transcription factor 1; Runt-related transcription factor 1; RUNX1/ZNF687 fusion; SL3-3 enhancer factor 1 alpha B subunit; SL3/AKV core-binding factor alpha B subunit; transcription factor
Gene Aliases: AML1; AML1-EVI-1; AMLCR1; CBF-alpha-2; CBF2alpha; CBFA2; EVI-1; Pebp2a2; PEBP2aB; PEBP2alpha; Pebpa2b; RUNX1
UniProt ID: (Human) Q01196, (Rat) Q63046
Entrez Gene ID: (Human) 861, (Rat) 50662, (Mouse) 12394
regulatory region DNA binding
RNA polymerase II regulatory region sequence-specific DNA binding
core promoter binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
protein binding
ATP binding
molecular_function
DNA binding
transcription factor activity, sequence-specific DNA binding
calcium ion binding
transcription factor binding
protein homodimerization activity
protein heterodimerization activity
repressing transcription factor binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
DNA-binding transcription factor
immunoglobulin fold transcription factor
Runt transcription factor
gene-specific transcriptional regulator
ossification
chondrocyte differentiation
transcription from RNA polymerase II promoter
hemopoiesis
positive regulation of granulocyte differentiation
positive regulation of interleukin-2 production
positive regulation of angiogenesis
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
peripheral nervous system neuron development
hematopoietic stem cell proliferation
skeletal system development
in utero embryonic development
liver development
myeloid progenitor cell differentiation
transcription, DNA-templated
regulation of transcription, DNA-templated
central nervous system development
negative regulation of cell proliferation
regulation of signal transduction
myeloid cell differentiation
neuron differentiation
negative regulation of granulocyte differentiation
hair follicle morphogenesis
response to retinoic acid
embryonic hemopoiesis
behavioral response to pain
neuron development
definitive hemopoiesis
regulation of hair follicle cell proliferation
cellular response to transforming growth factor beta stimulus
positive regulation of cell maturation
positive regulation of progesterone secretion
regulation of T cell anergy
regulation of transcription from RNA polymerase II promoter
positive regulation of interferon-gamma production
negative regulation of transcription, DNA-templated
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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