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Invitrogen
Phospho-RXRA (Ser260) Polyclonal Antibody
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FIGURE: 1 / 5
Phospho-RXRA (Ser260) Antibody (PA5-105942) in IHC (P)
Immunohistochemistry analysis of Phospho-RXRA (Ser260) in human ovarian cancer. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with Phospho-RXRA (Ser260) polyclonal antibody (Product # PA5-105942) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
Product Details
PA5-105942
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Non-human primate,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human RXRA(Accession P19793), corresponding to amino acid residues around phosphorylated Ser260.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
sequential chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of RXR alpha only when phosphorylated at Ser260.
Target Information
Retinoic Acid (RA; active metabolite of vitamin A) plays a prominent role in regulating the transition of proliferating precursor cells (such as carcinoma cells and neuronal precursors) to postmitotic differentiated cells. The Retinoid X Receptors (RXRs) family (RXR alpha, beta, and gamma), preferentially bind 9-cis -RA and regulate gene transcription by forming heterodimers with a second family of RA receptors. RAs have been suggested to potentially play a therapeutic role in cervical cancer. RAs are known to play key roles in neuronal development and an increasing body of evidence indicates that retinoid signaling may regulate synaptic plasticity and associated learning and memory behaviors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Nuclear receptor subfamily 2 group B member 1; Retinoic acid receptor RXR-alpha; retinoid X nuclear receptor alpha; retinoid X receptor; Retinoid X receptor alpha; retinoid X receptor, alpha; rxr alpha; RXR alpha 1
Gene Aliases: 9530071D11Rik; NR2B1; RXRA; RXRalpha1
UniProt ID: (Human) P19793, (Mouse) P28700
Entrez Gene ID: (Human) 6256, (Rat) 25271, (Mouse) 20181
RNA polymerase II regulatory region sequence-specific DNA binding
DNA binding
transcription factor activity, sequence-specific DNA binding
steroid hormone receptor activity
retinoic acid receptor activity
transcription coactivator activity
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
9-cis retinoic acid receptor activity
protein binding
zinc ion binding
enzyme binding
protein domain specific binding
chromatin DNA binding
protein complex binding
vitamin D receptor binding
retinoic acid receptor binding
sequence-specific DNA binding
transcription regulatory region DNA binding
retinoic acid-responsive element binding
protein heterodimerization activity
vitamin D response element binding
double-stranded DNA binding
transcription factor binding
metal ion binding
C4 zinc finger nuclear receptor
negative regulation of transcription from RNA polymerase II promoter
in utero embryonic development
liver development
maternal placenta development
transcription initiation from RNA polymerase II promoter
vitamin metabolic process
inflammatory response
midgut development
embryo implantation
aging
cholesterol metabolic process
negative regulation of cell proliferation
response to selenium ion
bile acid and bile salt transport
modulation by virus of host morphology or physiology
axon regeneration
regulation of myelination
response to retinoic acid
cellular response to insulin stimulus
response to vitamin A
response to vitamin D
peroxisome proliferator activated receptor signaling pathway
camera-type eye development
positive regulation of apoptotic process
steroid hormone mediated signaling pathway
cellular lipid metabolic process
response to ethanol
positive regulation of transcription from RNA polymerase II promoter
positive regulation of translational initiation by iron
retinoic acid receptor signaling pathway
protein homotetramerization
response to glucocorticoid
ventricular cardiac muscle tissue morphogenesis
ventricular cardiac muscle cell differentiation
cardiac muscle cell proliferation
secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development
regulation of branching involved in prostate gland morphogenesis
positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
placenta development
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
heart development
female pregnancy
response to nutrient
response to organic cyclic compound
positive regulation of transcription, DNA-templated
heart morphogenesis
negative regulation of gene expression
cardiac muscle cell differentiation
mesenchyme development
angiogenesis involved in coronary vascular morphogenesis
visceral serous pericardium development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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