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Invitrogen

Phospho-RXRA (Ser260) Polyclonal Antibody

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Phospho-RXRA (Ser260) Polyclonal Antibody

Product Details

PA5-105942

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:3,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-
Product Specifications

Species Reactivity

Human, Mouse, Non-human primate, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human RXRA(Accession P19793), corresponding to amino acid residues around phosphorylated Ser260.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

sequential chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2817341

Product Specific Information

Antibody detects endogenous levels of RXR alpha only when phosphorylated at Ser260.

Target Information

Retinoic Acid (RA; active metabolite of vitamin A) plays a prominent role in regulating the transition of proliferating precursor cells (such as carcinoma cells and neuronal precursors) to postmitotic differentiated cells. The Retinoid X Receptors (RXRs) family (RXR alpha, beta, and gamma), preferentially bind 9-cis -RA and regulate gene transcription by forming heterodimers with a second family of RA receptors. RAs have been suggested to potentially play a therapeutic role in cervical cancer. RAs are known to play key roles in neuronal development and an increasing body of evidence indicates that retinoid signaling may regulate synaptic plasticity and associated learning and memory behaviors.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: nuclear receptor subfamily 2 group B member 1; ORF-3; retinoid X nuclear receptor alpha; retinoid X receptor; rxr alpha; RXR alpha 1; unnamed protein product

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Gene Aliases: 9530071D11Rik; NR2B1; RXR-alpha; RXRalpha; RXRalpha1

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UniProt ID: (Human) P19793, (Mouse) P28700

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Entrez Gene ID: (Human) 6256, (Mouse) 20181, (Rat) 25271

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Function(s)
transcription regulatory region sequence-specific DNA binding RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding transcription cofactor binding transcription coactivator binding retinoic acid binding DNA binding double-stranded DNA binding transcription factor activity, sequence-specific DNA binding steroid hormone receptor activity transcription cofactor activity RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding protein binding zinc ion binding enzyme binding chromatin DNA binding peptide binding identical protein binding vitamin D receptor binding sequence-specific DNA binding retinoic acid-responsive element binding DBD domain binding LBD domain binding vitamin D response element binding sequence-specific double-stranded DNA binding protein domain specific binding retinoic acid receptor binding macromolecular complex binding thyroid hormone receptor binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter in utero embryonic development placenta development maternal placenta development positive regulation of thyroid hormone receptor signaling pathway heart morphogenesis regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter nervous system development heart development embryo implantation negative regulation of cell proliferation hormone-mediated signaling pathway gene expression negative regulation of gene expression cell differentiation monocyte differentiation positive regulation of bone mineralization intracellular steroid hormone receptor signaling pathway regulation of myelination response to retinoic acid peroxisome proliferator activated receptor signaling pathway mRNA transcription from RNA polymerase II promoter camera-type eye development positive regulation of apoptotic process positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of translational initiation by iron retinoic acid receptor signaling pathway cell maturation response to glucocorticoid cardiac muscle cell differentiation ventricular cardiac muscle tissue morphogenesis ventricular cardiac muscle cell differentiation cardiac muscle cell proliferation mesenchyme development secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development regulation of branching involved in prostate gland morphogenesis angiogenesis involved in coronary vascular morphogenesis visceral serous pericardium development positive regulation of vitamin D receptor signaling pathway cellular response to low-density lipoprotein particle stimulus nucleus-associated proteasomal ubiquitin-dependent protein catabolic process positive regulation of lipoprotein transport liver development midgut development female pregnancy response to nutrient response to selenium ion axon regeneration cellular response to insulin stimulus response to vitamin A response to vitamin D response to ethanol positive regulation of cholesterol efflux bile acid and bile salt transport regulation of lipid metabolic process positive regulation of lipid metabolic process
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