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Invitrogen

Phospho-RXRA (Ser260) Polyclonal Antibody

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View all (24) RXRA antibodies

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Phospho-RXRA (Ser260) Polyclonal Antibody

Product Details

PA5-64630

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
View 1 publication 1 publication
Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human RXR alpha (Phospho-Ser260)
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 30% glycerol, 0.87% NaCl

Contains

0.01% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2663160

Product Specific Information

Phospho-RXRA (Ser260) Polyclonal Antibody detects endogenous levels of RXRA only when phosphorylated at Ser260.

Target Information

Retinoic Acid (RA; active metabolite of vitamin A) plays a prominent role in regulating the transition of proliferating precursor cells (such as carcinoma cells and neuronal precursors) to postmitotic differentiated cells. The Retinoid X Receptors (RXRs) family (RXR alpha, beta, and gamma), preferentially bind 9-cis -RA and regulate gene transcription by forming heterodimers with a second family of RA receptors. RAs have been suggested to potentially play a therapeutic role in cervical cancer. RAs are known to play key roles in neuronal development and an increasing body of evidence indicates that retinoid signaling may regulate synaptic plasticity and associated learning and memory behaviors.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: Nuclear receptor subfamily 2 group B member 1; ORF-3; Retinoic acid receptor RXR-alpha; retinoid X nuclear receptor alpha; retinoid X receptor; Retinoid X receptor alpha; rxr alpha; RXR alpha 1; unnamed protein product

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Gene Aliases: 9530071D11Rik; NR2B1; RXR-alpha; RXRA; RXRalpha; RXRalpha1

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UniProt ID: (Human) P19793, (Mouse) P28700

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Entrez Gene ID: (Human) 6256, (Rat) 25271, (Mouse) 20181

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Function(s)
transcription regulatory region sequence-specific DNA binding RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcription cofactor binding retinoic acid binding DNA binding double-stranded DNA binding transcription factor activity, sequence-specific DNA binding steroid hormone receptor activity RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding protein binding zinc ion binding enzyme binding peptide binding identical protein binding vitamin D receptor binding sequence-specific DNA binding retinoic acid-responsive element binding metal ion binding DBD domain binding LBD domain binding vitamin D response element binding sequence-specific double-stranded DNA binding 9-cis retinoic acid receptor activity transcription factor binding protein domain specific binding chromatin DNA binding protein complex binding retinoic acid receptor binding transcription regulatory region DNA binding protein heterodimerization activity C4 zinc finger nuclear receptor
Process(es)
negative regulation of transcription from RNA polymerase II promoter positive regulation of thyroid hormone receptor signaling pathway regulation of transcription, DNA-templated nervous system development hormone-mediated signaling pathway positive regulation of cholesterol efflux cell differentiation monocyte differentiation positive regulation of bone mineralization intracellular steroid hormone receptor signaling pathway response to retinoic acid peroxisome proliferator activated receptor signaling pathway mRNA transcription from RNA polymerase II promoter positive regulation of lipid metabolic process positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter retinoic acid receptor signaling pathway cell maturation positive regulation of vitamin D receptor signaling pathway cellular response to low-density lipoprotein particle stimulus nucleus-associated proteasomal ubiquitin-dependent protein catabolic process positive regulation of lipoprotein transport in utero embryonic development liver development placenta development maternal placenta development transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter inflammatory response midgut development heart development female pregnancy embryo implantation aging response to nutrient negative regulation of cell proliferation response to selenium ion response to organic cyclic compound modulation by virus of host morphology or physiology axon regeneration regulation of myelination cellular response to insulin stimulus response to vitamin A response to vitamin D camera-type eye development positive regulation of apoptotic process steroid hormone mediated signaling pathway response to ethanol positive regulation of translational initiation by iron protein homotetramerization response to glucocorticoid ventricular cardiac muscle tissue morphogenesis ventricular cardiac muscle cell differentiation cardiac muscle cell proliferation secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development regulation of branching involved in prostate gland morphogenesis positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus heart morphogenesis negative regulation of gene expression cardiac muscle cell differentiation mesenchyme development angiogenesis involved in coronary vascular morphogenesis visceral serous pericardium development
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