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Invitrogen
Phospho-RXRA (Ser260) Polyclonal Antibody
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Product Details
PA5-64630
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human RXR alpha (Phospho-Ser260)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 30% glycerol, 0.87% NaCl
Contains
0.01% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Phospho-RXRA (Ser260) Polyclonal Antibody detects endogenous levels of RXRA only when phosphorylated at Ser260.
Target Information
Retinoic Acid (RA; active metabolite of vitamin A) plays a prominent role in regulating the transition of proliferating precursor cells (such as carcinoma cells and neuronal precursors) to postmitotic differentiated cells. The Retinoid X Receptors (RXRs) family (RXR alpha, beta, and gamma), preferentially bind 9-cis -RA and regulate gene transcription by forming heterodimers with a second family of RA receptors. RAs have been suggested to potentially play a therapeutic role in cervical cancer. RAs are known to play key roles in neuronal development and an increasing body of evidence indicates that retinoid signaling may regulate synaptic plasticity and associated learning and memory behaviors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Nuclear receptor subfamily 2 group B member 1; ORF-3; Retinoic acid receptor RXR-alpha; retinoid X nuclear receptor alpha; retinoid X receptor; Retinoid X receptor alpha; rxr alpha; RXR alpha 1; unnamed protein product
Gene Aliases: 9530071D11Rik; NR2B1; RXR-alpha; RXRA; RXRalpha; RXRalpha1
UniProt ID: (Human) P19793, (Mouse) P28700
Entrez Gene ID: (Human) 6256, (Rat) 25271, (Mouse) 20181
transcription regulatory region sequence-specific DNA binding
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcription cofactor binding
retinoic acid binding
DNA binding
double-stranded DNA binding
transcription factor activity, sequence-specific DNA binding
steroid hormone receptor activity
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
protein binding
zinc ion binding
enzyme binding
peptide binding
identical protein binding
vitamin D receptor binding
sequence-specific DNA binding
retinoic acid-responsive element binding
metal ion binding
DBD domain binding
LBD domain binding
vitamin D response element binding
sequence-specific double-stranded DNA binding
9-cis retinoic acid receptor activity
transcription factor binding
protein domain specific binding
chromatin DNA binding
protein complex binding
retinoic acid receptor binding
transcription regulatory region DNA binding
protein heterodimerization activity
C4 zinc finger nuclear receptor
negative regulation of transcription from RNA polymerase II promoter
positive regulation of thyroid hormone receptor signaling pathway
regulation of transcription, DNA-templated
nervous system development
hormone-mediated signaling pathway
positive regulation of cholesterol efflux
cell differentiation
monocyte differentiation
positive regulation of bone mineralization
intracellular steroid hormone receptor signaling pathway
response to retinoic acid
peroxisome proliferator activated receptor signaling pathway
mRNA transcription from RNA polymerase II promoter
positive regulation of lipid metabolic process
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
retinoic acid receptor signaling pathway
cell maturation
positive regulation of vitamin D receptor signaling pathway
cellular response to low-density lipoprotein particle stimulus
nucleus-associated proteasomal ubiquitin-dependent protein catabolic process
positive regulation of lipoprotein transport
in utero embryonic development
liver development
placenta development
maternal placenta development
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
inflammatory response
midgut development
heart development
female pregnancy
embryo implantation
aging
response to nutrient
negative regulation of cell proliferation
response to selenium ion
response to organic cyclic compound
modulation by virus of host morphology or physiology
axon regeneration
regulation of myelination
cellular response to insulin stimulus
response to vitamin A
response to vitamin D
camera-type eye development
positive regulation of apoptotic process
steroid hormone mediated signaling pathway
response to ethanol
positive regulation of translational initiation by iron
protein homotetramerization
response to glucocorticoid
ventricular cardiac muscle tissue morphogenesis
ventricular cardiac muscle cell differentiation
cardiac muscle cell proliferation
secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development
regulation of branching involved in prostate gland morphogenesis
positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
heart morphogenesis
negative regulation of gene expression
cardiac muscle cell differentiation
mesenchyme development
angiogenesis involved in coronary vascular morphogenesis
visceral serous pericardium development
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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