This Antibody was verified by KnockOut to ensure that the antibody binds to the antigen stated. View Details
Raf-1 is a MAP kinase kinase kinase (MAP3K) which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated Raf-1 can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2 which in turn phosphorylate to activate the serine/threonine specific protein kinases ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration.
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Protein Aliases: C-Raf; C-Raf proto-oncogene, serine/threonine kinase; CRAF; EC 188.8.131.52; kinase Raf1; Oncogene RAF1; Protein kinase raf 1; Proto-oncogene c-RAF; raf proto-oncogene serine/threonine protein kinase; RAF proto-oncogene serine/threonine-protein kinase; Raf-1; RAF1; Similar to murine leukemia viral (V-raf-1) oncogene homolog 1; v-raf-1 murine leukemia viral oncogene homolog 1; v-raf-1 murine leukemia viral oncogene-like protein 1
Gene Aliases: c-Raf; CMD1NN; CRAF; NS5; RAF; Raf-1; RAF1
UniProt ID: (Human) P04049
Entrez Gene ID: (Human) 5894