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Fabgennix
Phospholipase A2 Polyclonal Antibody
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Product Details
PLAP2-212AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Human,
Non-human primate
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide taken within amino acid region 450-500 on human Phospholipase A2-activating protein.
Conjugate
Form
Liquid
Concentration
0.5-1.5 mg/mL
Purification
Affinity chromatography
Storage buffer
proprietary buffer, pH 7.4-7.8, with 0.5% BSA, 30% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Phospholipase A2 catalyzes the release of fatty acids from glycero-3-phosphocholines. The best known varieties are the digestive enzymes secreted as zymogens by the pancreas of mammals. Sequences of pancreatic PLA2 enzymes from a variety of mammals have been reported. One striking feature of these enzymes is their close homology to venom phospholipases of snakes. Other forms of PLA2 have been isolated from brain, liver, lung, spleen, intestine, macrophages, leukocytes, erythrocytes, inflammatory exudates, chondrocytes, and platelets.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Group IB phospholipase A2; MGC119834; MGC119835; Phosphatidylcholine 2-acylhydrolase 1B; Phospholipase A2; phospholipase A2, group IB (pancreas); unnamed protein product
Gene Aliases: PLA2; PLA2A; PLA2G1B; PPLA2
UniProt ID: (Human) P04054, (Bovine) P00593
Entrez Gene ID: (Human) 5319, (Bovine) 282457
phospholipase A2 activity
receptor binding
calcium ion binding
phospholipid binding
hydrolase activity
bile acid binding
metal ion binding
calcium-dependent phospholipase A2 activity
phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)
phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)
phospholipase
innate immune response in mucosa
neutrophil mediated immunity
lipid metabolic process
fatty acid biosynthetic process
phospholipid metabolic process
actin filament organization
signal transduction
positive regulation of cell proliferation
positive regulation of calcium ion transport into cytosol
lipid catabolic process
leukotriene biosynthetic process
antibacterial humoral response
neutrophil chemotaxis
positive regulation of interleukin-8 production
cellular response to insulin stimulus
intracellular signal transduction
positive regulation of MAPK cascade
positive regulation of transcription from RNA polymerase II promoter
regulation of glucose import
phosphatidylcholine metabolic process
phosphatidylglycerol metabolic process
positive regulation of fibroblast proliferation
arachidonic acid secretion
positive regulation of protein secretion
positive regulation of immune response
defense response to Gram-positive bacterium
antimicrobial humoral immune response mediated by antimicrobial peptide
positive regulation of glomerular visceral epithelial cell apoptotic process
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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