Search
Bioss
Plasminogen Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
FIGURE: 1 / 1
Plasminogen Antibody (BS-1828R) in IHC (P)
Paraformaldehyde-fixed, paraffin embedded human liver; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with Plasminogen Polyclonal Antibody, Unconjugated (bs-1828R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) ... View More
Product Details
BS-1828R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human PLG, amino acids 251-350.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Plasminogen is a plasma protein synthesized mostly in the liver. It consists of a single polypeptide chain and has a molecular weight of 88.5 kDa. The plasma concentration is usually in the range of 70 - 200 mg/L. Plasminogen is activated by tissue-plasminogen activator, urokinase and streptokinase, to form plasmin. Activation results from the cleavage and release of the preactivation peptide. Plasmin consists of a heavy (A-) chain which contains 5 kringles and a light (B-) chain with the active site. Plasmin is a trypsin-like protease whose natural substrate is fibrin, with binding sites for fibrin residing on the kringles. Plasmin is essential for fibrinolysis and decreased fibrinolytic potential due to congenital defects in plasmin can lead to recurring thrombosis, thrombophlebitis and pulmonary embolism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: angiostatin; DKFZp779M0222; plasmin; plasmin heavy chain A; plasmin light chain B; Plasminogen; RP1-81D8.1; unnamed protein product
Gene Aliases: Ab1-346; AI649309; HAE4; Pg; PLG
UniProt ID: (Human) P00747, (Mouse) P20918, (Rat) Q01177
Entrez Gene ID: (Human) 5340, (Mouse) 18815, (Rat) 85253
protease binding
endopeptidase activity
serine-type endopeptidase activity
receptor binding
protein binding
peptidase activity
serine-type peptidase activity
hydrolase activity
enzyme binding
kinase binding
protein domain specific binding
apolipoprotein binding
chaperone binding
protein antigen binding
serine protease
proteolysis
blood coagulation
hemostasis
negative regulation of cell proliferation
negative regulation of cell-substrate adhesion
protein processing
extracellular matrix disassembly
tissue regeneration
fibrinolysis
positive regulation of blood vessel endothelial cell migration
myoblast differentiation
muscle cell cellular homeostasis
tissue remodeling
interaction with symbiont
negative regulation of fibrinolysis
positive regulation of fibrinolysis
trophoblast giant cell differentiation
labyrinthine layer blood vessel development
mononuclear cell migration
trans-synaptic signaling by BDNF, modulating synaptic transmission
negative regulation of cell-cell adhesion mediated by cadherin
negative regulation of angiogenesis
proteolysis involved in cellular protein catabolic process
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support