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Plasminogen Antibody (PA5-14196) in IHC (P)
Immunohistochemistry analysis of Plasminogen in formalin-fixed and paraffin-embedded human hepatocarcinoma. Samples were incubated with Plasminogen polyclonal antibody (Product # PA5-14196) which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Product Details
PA5-14196
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 636-665 amino acids from the C-terminal region of human PLG
Conjugate
Unconjugated
Form
Liquid
Concentration
2 mg/mL
Purification
Size-exclusion - Dialysis, Ammonium sulfate precipitation
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2252642
Target Information
Plasminogen is a plasma protein synthesized mostly in the liver. It consists of a single polypeptide chain and has a molecular weight of 88.5 kDa. The plasma concentration is usually in the range of 70 - 200 mg/L. Plasminogen is activated by tissue-plasminogen activator, urokinase and streptokinase, to form plasmin. Activation results from the cleavage and release of the preactivation peptide. Plasmin consists of a heavy (A-) chain which contains 5 kringles and a light (B-) chain with the active site. Plasmin is a trypsin-like protease whose natural substrate is fibrin, with binding sites for fibrin residing on the kringles. Plasmin is essential for fibrinolysis and decreased fibrinolytic potential due to congenital defects in plasmin can lead to recurring thrombosis, thrombophlebitis and pulmonary embolism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DKFZp779M0222; plasmin; Plasminogen; RP1-81D8.1
Gene Aliases: PLG
UniProt ID: (Human) P00747
Entrez Gene ID: (Human) 5340
platelet degranulation
proteolysis
blood coagulation
negative regulation of cell proliferation
negative regulation of cell-substrate adhesion
extracellular matrix disassembly
fibrinolysis
cellular protein metabolic process
tissue remodeling
negative regulation of fibrinolysis
positive regulation of fibrinolysis
negative regulation of cell-cell adhesion mediated by cadherin
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